DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt1b4

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001166239.2	Gene:	ugt1b4 / 795050	ZFINID:	ZDB-GENE-080227-13	Length:	533	Species:	Danio rerio

Alignment Length:	555	Identity:	139/555 - (25%)
Similarity:	244/555 - (43%)	Gaps:	106/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLAILGLALGQI---------SQAAKILVLFPHVNEGHFAVMRTLVTELANREHTI-----EVY 59
            |:..::|:....:         |...|:||:  .::..|:..::.:..|:..|.||:     |:.
Zfish    10 IICLVVGVVCSAVVDQKLSRNSSWTGKLLVV--PMDGSHWTGVKAVAEEMGRRGHTVIVVIPEIS 72

  Fly    60 TGHGLGESLDNVTETVTAEFP--FWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGA------- 115
            ...|.|:      ..:|.:||  :..:|..|            :.:|.:.:..||..:
Zfish    73 MRLGPGK------HYITKKFPVQYKQDLINQ------------IMVEHVNEVAASEQSLLKTVTS 119

  Fly   116 ------RALDHFLA------QEPIQKLLKMSYLEF----DFDVILVDYFYTEALLALGAL----H 160
                  :.:|||::      ||  |:|     :||    :||.:|     |...:.:||:    .
Zfish   120 IMYRFGKIIDHFISTSESLFQE--QEL-----IEFLRDQNFDAVL-----TNPAMPMGAILAYNL 172

  Fly   161 QRPVV----GII----STDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRK 217
            ..|.|    ||:    :|...|          |.:..|..|.:....|:||.|:  |.|.::..:
Zfish   173 SVPAVYMLRGIMCESKATACPN----------PPSYIPRFFTQISDRMTFSERV--INTLVSLLE 225

  Fly   218 QFI-KDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGP 281
            ..: :...|..|::.:|:.....||.|: .|..:|.|:.....|..||..:..:|..||::....
Zfish   226 PLMCRLMLGSFEEMTSKFLHRDVSITEI-LSTAAVWLMRYDFTLEFPKPLMPNMITIGGINCEVK 289

  Fly   282 KELPWNVKRFLE-EARPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGL 345
            ..|...|:.|:. ....|.:...||:  ....:||||.|..|..||...|.::|. :..:....:
Zfish   290 NPLTKEVEEFVNGSGEHGIVVFSLGS--LVSSMPKEKADIFFKAFSMIPQRVLWR-YTGEIPNNV 351

  Fly   346 PKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVG 410
            |:||.:...:||.|:|.||:.:||:|:|....:.|||...||::.||||..:|.|:......|||
Zfish   352 PENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATRGVG 416

  Fly   411 LQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALR 475
            :.|...::|.|:|..|::.::..|.::..::.:|....|||:..|..|:||..:|.||||...||
Zfish   417 VILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLR 481

  Fly   476 TRGIGISSCQLHLFDLFVFYAGIATLVVSLLVALS 510
            .....::..|.|..|:..|     .|::.|:|.|:
Zfish   482 PAAHELNWLQYHSLDVIGF-----MLLIVLIVTLA 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	129/498 (26%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	136/530 (26%)
ugt1b4	NP_001166239.2	UDPGT	35..529	CDD:278624	136/530 (26%)
ugt1b4	NP_001166239.2	egt	<273..512	CDD:223071	75/247 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900