DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	527	Identity:	125/527 - (23%)
Similarity:	221/527 - (41%)	Gaps:	54/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTET 74
            ||..|.|....:..:.::||:....:  |:..||.::..|.:|.|::.|.    :..|...|..|
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYS--HWHNMRAIIEALVDRNHSVTVL----VSSSSPTVPHT 64

  Fly    75 VTAEFPF---------------WSEL----QKQAAPKGNLADLGLLPIEKLRQSLASVGARALDH 120
            ..|.|.:               ||:.    .|:...|   .:.|.| |.::..:...:.|.....
Zfish    65 QKARFDYHVFKVNMDKEEAKVIWSDFTHLWMKETDSK---LERGFL-IWRVMSNFRRLAADVCRS 125

  Fly   121 FLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALVP 185
            .|..:.:.::|..|:    :||:..|.....:.|....|:...|:.:..|....:.....:...|
Zfish   126 LLQNDDLLQMLGESH----YDVLFSDPMMPCSDLMAQTLNIPQVISLRLTFAYTFERMCGQMPAP 186

  Fly   186 AACSP----IDFERDQPEMSFSVRLGN-----IRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSI 241
            .:..|    .|...|:  |||..|:.|     |.|.:.|....:.     .::|.|:.....:::
Zfish   187 PSYVPAVALTDHLTDR--MSFMERVENMLLYFIHTTVFRLNTMLT-----VDRLYTEIRGKPTTM 244

  Fly   242 PELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARP-GAIYVQLG 305
            .|.. .:..:.|:.::.....|:.........||||.:..|.|...::.|::.:.. |.:...||
Zfish   245 CETM-GKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVVFSLG 308

  Fly   306 NEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFL 370
            :  ....|..|:.:|:.|......|.::|. :..||.|.|..|..|...:||.|:|.||:.|||:
Zfish   309 S--MIKNLTSERANTIAAALGQIPQKVVWR-YSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFI 370

  Fly   371 TNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESH 435
            |:|....|.|.|...||::|||||..:..|:......|..:.|:...:.::.|..|:..:|....
Zfish   371 THGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPS 435

  Fly   436 FQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIAT 500
            ::.:|..:|....|:|:..|..|::|:.:|.|:||...||.:...:|..|.|..|:..|...||.
Zfish   436 YKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAA 500

  Fly   501 LVVSLLV 507
            |:..|.|
Zfish   501 LITFLWV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	111/483 (23%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	121/512 (24%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	121/512 (24%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	65/233 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910