DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	534	Identity:	131/534 - (24%)
Similarity:	228/534 - (42%)	Gaps:	52/534 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SQWNRWILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGES 67
            |.|...|.:      .|.:....||||  ..:...|:..|..|:..|..:.||::|.........
Zfish    33 SLWTTVITI------FGSLCDGGKILV--APLEGSHWVNMDILIKALHGQGHTVDVIRNANSWFI 89

  Fly    68 LDNVT--ETVT------------AEFPFWSELQKQAAPKGNLADLGLL------PIEKLRQSLAS 112
            .:|.|  :|:|            |:|.:  ::.|....||:...:..|      .::|..:.:..
Zfish    90 KENSTYYDTITIPNTKGWDEEFAADFVY--KMIKYEKEKGSWLSIVRLYLNVFDAVKKTHEMVCQ 152

  Fly   113 VGARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFG-NYM 176
            :....||    .|.|.|:|.    |..:|::|.|..:...::....|....|..:..|..| .:.
Zfish   153 LITNILD----SEEILKMLN----EKQYDLMLTDPVWGTGIILAHKLKLPMVYNVRWTTTGEGHF 209

  Fly   177 DAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSI 241
            |.   |..|.:..||....:...|||..||.|....:....|....:....:.:..|||..:.:.
Zfish   210 DI---APSPMSYIPITGSGNTDRMSFFQRLKNYFFYLLLDLQLSHFNVKQYQAICDKYFTSRVNF 271

  Fly   242 PE-LQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARP-GAIYVQL 304
            .| ||.:.|  .|:........|:.::..||..||......|.||.:::.|::.:.. |.|.:.|
Zfish   272 HELLQGADL--WLMRVDFVFEFPRPTMPNIIYIGGFQCPPAKPLPHDLEDFMQSSGDHGVIVMSL 334

  Fly   305 GNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAF 369
            |:  ..|.||:.....:.|.|:...|.:||. :..|....|..|.::...:||.|:|.||:.|.|
Zfish   335 GS--LIGNLPENVTAEIAAAFARLPQKVIWR-YTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVF 396

  Fly   370 LTNGDLLNLQEGIMRNVPILGLPLFQHEARNM-ELAVRLGVGLQLEEGNVTTESLNWAVDRLLLE 433
            :::|....:.|.:...||::|:|.|..:..|: .|..|.|..| |...::...:|:.|:..::.|
Zfish   397 ISHGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKL-LSIADLGENTLHAAIQEVINE 460

  Fly   434 SHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFV-FYAG 497
            ..::|.:..:|...:|:|:..|.||:||:.:|.||||.:.|||....:.....|..|:.| .:|.
Zfish   461 PSYRLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVVVTLFAV 525

  Fly   498 IATLVVSLLVALSF 511
            :..|...:.|.:.:
Zfish   526 VLILTYCIFVTVRY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	120/478 (25%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	127/512 (25%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	127/512 (25%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	69/243 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810