DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and UGT8

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	567	Identity:	139/567 - (24%)
Similarity:	231/567 - (40%)	Gaps:	119/567 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLD-------- 69
            :|..|:| |::||||:::.|.:.|.|..:.:||.:.|..|.|    :|...|.|..|
Human    10 LLWSAVG-IAKAAKIIIVPPIMFESHMYIFKTLASALHERGH----HTVFLLSEGRDIAPSNHYS 69

  Fly    70 -----NVTETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLA------ 123
                 .:..:.|::....|:::...:  |.|..:.|..|              |||:..
Human    70 LQRYPGIFNSTTSDAFLQSKMRNIFS--GRLTAIELFDI--------------LDHYTKNCDLMV 118

  Fly   124 --QEPIQKLLKMSYLEFDFDVILVD-----YFYTEALLALGALHQRPVVGIISTDFGNYMDAVQE 181
              ...||.|.|..     ||::|||     .|....||.:       ...:.||  |.:..|...
Human   119 GNHALIQGLKKEK-----FDLLLVDPNDMCGFVIAHLLGV-------KYAVFST--GLWYPAEVG 169

  Fly   182 ALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQ---FIKDHYGGQEQLVTKY---FQLQSS 240
            |..|.|..|          .|:..|.:....:.|.|.   ::....|....::.||   .|..:.
Human   170 APAPLAYVP----------EFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNL 224

  Fly   241 IPELQASQL----SVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARP-GAI 300
            :||.....|    |:.:|.:.|.|..|:.::..::..||:..:....||.:::|::..|.. |.:
Human   225 LPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFV 289

  Fly   301 YVQLG------NEQ-------ACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQ 352
            .|..|      :|.       |.|:||               |.:||.....|. :.|..|..:.
Human   290 LVSFGAGVKYLSEDIANKLAGALGRLP---------------QKVIWRFSGPKP-KNLGNNTKLI 338

  Fly   353 HAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGN 417
            ..:||.|:|.|.::||||::|.|.::.|.|...||::|:|||......|......|:|:.||...
Human   339 EWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKT 403

  Fly   418 VTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGIS 482
            ||.:.|..|:.:::....::...:.:|...:|:|...:...::|::|:.||.|...||.....||
Human   404 VTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQIS 468

  Fly   483 SCQLHLFDL-FVFYAGIATLVVSLLVALSFGGFY-----IWNKKNNS 523
            .||..|.|: ||...|.|.|...|.....|  .|     :|::..:|
Human   469 FCQYFLLDIAFVLLLGAALLYFLLSWVTKF--IYRKIKSLWSRNKHS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	119/504 (24%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	131/539 (24%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	132/542 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910