Protein Alignment Ugt317A1 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_611694.2
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 121/569 - (21%)
• Similarity: 218/569 - (38%)
• Gaps: 84/569 - (14%)

  Fly     1 MESQWNRWILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREH----------- 54
            |..:|...|||..|...... ....|:||.....:  |:..::|::.||..|.|
Human     1 MSVKWTSVILLIQLSFCFSS-GNCGKVLVWAAEYS--HWMNIKTILDELIQRGHEVTVLASSASI 62

  Fly    55 ----------TIEVYTGHGLGESLDNVTETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQS 109
                      .||:|........|:|.   :..:...||:|.|         |...|...:: |.
Human    63 LFDPNNSSALKIEIYPTSLTKTELENF---IMQQIKRWSDLPK---------DTFWLYFSQV-QE 114

  Fly   110 LASVGARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGN 174
            :.|:.......|.......|.......|..||||..|..:..:.| |..|...|.|..:|...|.
Human   115 IMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSEL-LAELFNIPFVYSLSFSPGY 178

  Fly   175 YMDAVQEALV-PAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQ 238
            ..:......: |.:..|:.......:|:|..|:.|:                    :...||...
Human   179 TFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNM--------------------IYVLYFDFW 223

  Fly   239 SSIPEL------------QASQLSVLLLNSHVPLITPKVSIQ---QIIP----AGGLHIRGPKEL 284
            ..|.::            :.:.||..:..:.|.||....:.|   .::|    .||||.:..|.|
Human   224 FEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPL 288

  Fly   285 PWNVKRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKN 348
            |..::.|::.: ..|.:...||:  ....:.:|:.:.:.:..:...|.::|. .|....:.|..|
Human   289 PKEMEDFVQSSGENGVVVFSLGS--MVSNMTEERANVIASALAQIPQKVLWR-FDGNKPDTLGLN 350

  Fly   349 VMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQL 413
            ..:...:||.|:|.||:.:||:|:|....:.|.|...:|::|:|||..:..|:......|..:::
Human   351 TRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRV 415

  Fly   414 EEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRG 478
            :...:::..|..|:.|::.:..::..:..:|....|:|:..|..|:||:.:|.||||...||...
Human   416 DFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA 480

  Fly   479 IGISSCQLHLFDLFVFYAGIATLVVSLLVALSFGGFYIWNKKNNSKSTK 527
            ..::..|.|..|:..|.......|:.::.....  |..|.....:|..|
Human   481 HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCL--FCFWKFARKAKKGK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_611694.2	GT1_Gtf-like	25..431	CDD:340817	92/447 (21%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	113/541 (21%)