DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and ugt5b6

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001035435.1	Gene:	ugt5b6 / 678597	ZFINID:	ZDB-GENE-060421-3572	Length:	531	Species:	Danio rerio

Alignment Length:	573	Identity:	136/573 - (23%)
Similarity:	241/573 - (42%)	Gaps:	93/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESQWNRWIL---LAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEV---- 58
            |..|:.:.||   |.|| |....:.|:.|:|| || |:..|:..|:.||..|..:.|.|.|
Zfish     1 MNGQFFKVILPVTLTIL-LVTVPVVQSGKVLV-FP-VDVSHWVNMKILVEALHAKGHNITVMRMA 62

  Fly    59 -----------YT------GHGLGES-LDNVTETVTA---EFPFWSELQKQAAPKGNLADLGLLP 102
                       ||      ..|.||. |:.....:.|   |...|..|:.:|            .
Zfish    63 DSWYIKEFSPHYTSINLKSAGGFGEDFLETFASRLMAILREGSIWGRLKLEA------------E 115

  Fly   103 IEKLRQSLASVGARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGI 167
            :.:....:....:..:.:.:..:.:.:|||    :..:||||.|......:: ||...:.|:|
Zfish   116 VWQTTWKMIETESVMIVNMIEDQKLMQLLK----DAKYDVILTDPTIFGGVI-LGHYLKLPMV-- 173

  Fly   168 ISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNI-RTC---------------IARR 216
            .:..:..|.:| ..|:.|:..|.:.|    |.:..|.|:..: |.|               ||..
Zfish   174 YNARWTIYSEA-HFAIAPSPLSYVPF----PSLELSDRMSFLERVCNVVMYTIIEIGAALVIAPI 233

  Fly   217 KQFIKDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLI--TPKVSIQQIIPAGGLHIR 279
            ...:.:.:.|..   |.|..|      :|.:.|.:    ..|..:  .|:.::..|:...|...:
Zfish   234 NDALAERFIGPG---TSYLSL------VQGADLWL----HRVDFVFEYPRPTMPNIVYMAGFQCK 285

  Fly   280 GPKELPWNVKRFLEEARP-GAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLE 343
            ..|.||.:::.|::.:.. |.|.:.||.  ..||||::..:.:...|:...|.|||. :..|...
Zfish   286 PSKPLPQDLEDFVQSSGDHGVIIMSLGT--LIGQLPEDVAEAIAEAFAELPQKIIWR-YKGKRPS 347

  Fly   344 GLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNM-ELAVRL 407
            .|..|.::...:||.|:|.|.:.:||:.:|....:||.|...|||:|..|...:..|: ::.||
Zfish   348 ALGNNTLVMDWMPQNDLLGHSKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVR- 411

  Fly   408 GVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGS 472
            |....::...:..||....|..:|....::..::.:|...:|.|:..|.:|:||:.:|.||||.:
Zfish   412 GAAKNVDFATMDKESFLKTVKEVLYNPTYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAA 476

  Fly   473 ALRTRGIGISSCQLHLFD-LFVFYAGIATLVVSLLVALSFGGFYIWNKKNNSK 524
            .|||....:.....|..| :.|..:.::.:::::...:.:....|..||..||
Zfish   477 HLRTESNKMPWYSYHSVDVILVLISAVSLIILTIFAVIRYFCCRICMKKTKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	119/499 (24%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	122/534 (23%)
ugt5b6	NP_001035435.1	egt	5..501	CDD:223071	129/539 (24%)
ugt5b6	NP_001035435.1	UDPGT	27..529	CDD:278624	125/544 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000