DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	563	Identity:	136/563 - (24%)
Similarity:	230/563 - (40%)	Gaps:	127/563 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTET 74
            ||.:|....|     .|:|| || ::..|:..|:.|:.||..:.|.:.|..        .:.:..
Zfish    12 LLCVLSGTYG-----GKVLV-FP-LDGSHWVNMKVLIEELHRKGHNVTVVR--------PSNSWY 61

  Fly    75 VTAEFPFWSELQKQAAPK-------------GNLADL---GLLPIEKLR---------QSLASVG 114
            :..|.||:|.:   ..|.             ..|.::   |...:.::|         :::....
Zfish    62 IKEESPFYSSI---TIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDM 123

  Fly   115 ARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVG---IISTDFG--- 173
            .:.:|..|..|.:..    |..:..|||:|.|                |.||   |::..|.
Zfish   124 LQMMDRMLEDEKVMN----SIQDAKFDVVLAD----------------PAVGGGPILAYKFNIPL 168

  Fly   174 --NYMDAVQE----ALVPAACS--PIDFERDQPEMSFSVRLGNIRTCIARRKQ-----------F 219
              |....:|.    |:.|:..|  |:.......:|||..|:.|:...:..:.|           |
Zfish   169 VFNVRWTIQGEGHFAIAPSPLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPF 233

  Fly   220 IKDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKEL 284
            ...|:|..   || ||.|        .....:.|:.:......|:.::..|:...|...:..|.|
Zfish   234 CHKHFGPN---VT-YFSL--------FQDADIWLMRNDFTFEFPRPTMPNIVYMSGFQCKPAKPL 286

  Fly   285 PWNVKRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKN 348
            |.::::|:|.: ..|.|.:.||.  ...|||::..|.:.|.|:...|.:||.....:.:. |..|
Zfish   287 PNDLEKFVESSGEHGVIVMSLGT--LIAQLPQDMTDDIAAAFAELPQKVIWRYTGPRPVT-LGNN 348

  Fly   349 VMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLP--------LFQHEARNMELAV 405
            .::...:||.|:|.||::|.|:.:|....:||.|...|||||||        ||:.||:.....|
Zfish   349 TLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIV 413

  Fly   406 RLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKG 470
            .:..   |:: .|..|:|.    .:|....::..::.:|....|:||..|..|:||:.:|.|:||
Zfish   414 DIAT---LDK-TVFLEALK----EVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKG 470

  Fly   471 GSALRTRGIGISSCQLHLFDLFVFYAGIATLVVS-LLVALSFG 512
            ...|||:...:|..:.|..|:      |.||:|: .:.||..|
Zfish   471 APHLRTQSFRMSWIEYHSIDV------ILTLMVTGFVFALMIG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	121/513 (24%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	132/548 (24%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	132/548 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810