DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt8

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	574	Identity:	124/574 - (21%)
Similarity:	222/574 - (38%)	Gaps:	115/574 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVT 72
            ::|..:|......:|.||||:|:.|.:.|.|..:.:||.:.|....|........|
Zfish     5 FVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVSEG--------- 60

  Fly    73 ETVTAEFPFWSELQKQAAP--------------------KGNLADLGLLPIEKLRQSLASVGARA 117
                .|.|..:..:.|..|                    .|.|..|.|..|
Zfish    61 ----REIPPSNHYRLQRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDI-------------- 107

  Fly   118 LDHF-------LAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGNY 175
            |||:       :....:.:.||..:    ||::|||   ...:......|   ::|:....|...
Zfish   108 LDHYSQNCDAVVGSTSVMEQLKREH----FDLLLVD---PNEMCGFVIAH---ILGVQYAVFSTG 162

  Fly   176 MDAVQEALVPAACSPIDFERDQPE--------MSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVT 232
            :....|...||..|.:      ||        ||...|:.|....:..|       :|.|..::.
Zfish   163 LWYPAEVGAPAPLSYV------PEFNSLLTDHMSLFQRVANTAVYLVSR-------FGVQFLVLP 214

  Fly   233 KY------FQLQSSIPELQASQLSVL-LLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKR 290
            ||      :.:|.|:......|.|.| :|.:.:.|..|:.::..::..||:..:.|..||...:.
Zfish   215 KYDRIMRKYNIQPSVSMHDLVQNSRLWMLCTDMALEFPRPTLPHVVYVGGILTKPPSPLPQEFET 279

  Fly   291 FLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHA 354
            ::::. ..|.:.|..|  .....|..:....|....|...|.:||....|.. ..|..|..:...
Zfish   280 WVKDTDEDGFVVVSFG--AGVKYLSDDIAQKLAGALSRLPQRVIWRFSGVPP-SNLGNNTKLVDW 341

  Fly   355 VPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVT 419
            :||.|:|.....:|||::|.|.::.|.:...||::|:|||......|......|:|:.||...::
Zfish   342 MPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMS 406

  Fly   420 TESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSC 484
            .|.|..|:..::.:..::...:.:|...:|:|...::.|::|::|:.||:|...||:....|.:.
Zfish   407 EEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTY 471

  Fly   485 QLHLFDLFVFYAGIATLVVSLLVALSFGGFYIWN---------KKNNSKSTKVN 529
            |..|.|:        .:|:.:.:.|:  |:.::.         .:.:|...|||
Zfish   472 QYFLLDV--------AMVIGVCLLLT--GYCLYRIVKFIQFRLGRGSSPGEKVN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	111/497 (22%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	115/531 (22%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	116/540 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000