Protein Alignment Ugt317A1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_001286734.1
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 119/551 - (21%)
• Similarity: 213/551 - (38%)
• Gaps: 107/551 - (19%)

  Fly     8 WILLA-ILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREH-----TIEV-------- 58
            |:... :|.|::...:::.|:||:  .::..|:..||.::.||..|.|     |.||
Human    11 WLATGLLLLLSVQPWAESGKVLVV--PIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEEN 73

  Fly    59 ---YTGHGLGESLDNVTETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDH 120
               .|.:.:..:.|.....|......:.|.:..              ::|..:|:|.:...:|.:
Human    74 FFTLTTYAISWTQDEFDRHVLGHTQLYFETEHF--------------LKKFFRSMAMLNNMSLVY 124

  Fly   121 ------FLAQEPIQKLLKMSYLEFDFDVILVD-----------YFYTEALLAL----------GA 158
                  .|..|.:.:.|..:    .|||:|.|           |.....:..|          |.
Human   125 HRSCVELLHNEALIRHLNAT----SFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGT 185

  Fly   159 LHQRP---VVGIIST--DFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQ 218
            ....|   :..:::|  |...:|..|:..|.|.|.|.|......|..|
Human   186 QCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYAS----------------- 233

  Fly   219 FIKDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKE 283
                       |.::.||.:.|:.:: .|..||.|......:..|:..:..::..||::....|.
Human   234 -----------LASELFQREVSVVDI-LSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKP 286

  Fly   284 LPWNVKRFLE-EARPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPK 347
            |....:.::. ....|.:...||:  ...::|::|...:........|:::|.....:. ..|..
Human   287 LSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRP-SNLAN 348

  Fly   348 NVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQ 412
            |.::...:||.|:|.||..:||:|:.....:.|.|...||::.:|||..:..|.:.....|.|:.
Human   349 NTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVT 413

  Fly   413 LEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTR 477
            |....:|:|.|..|:..::.:..::..|..:|...:|||:..|..|:|||.:|.||||...||..
Human   414 LNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPA 478

  Fly   478 GIGISSCQLHLFDLFVFYAGIATLVVSLLVA 508
            ...::..|.|..|:..|     .|.|.|.||
Human   479 AHDLTWYQYHSLDVIGF-----LLAVVLTVA 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	107/503 (21%)
		UDPGT	25..514	CDD:278624	116/533 (22%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	116/533 (22%)
		egt	<262..508	CDD:223071	64/251 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810