Protein Alignment Ugt317A1 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_611694.2
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 119/531 - (22%)
• Similarity: 209/531 - (39%)
• Gaps: 78/531 - (14%)

  Fly    13 ILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTETVTA 77
            :|.|::...:::.|:||:  ..:...:..||..:.||..|.|...|.|........:....|:||
Human    17 LLLLSVQPWAESGKVLVV--PTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTA 79

  Fly    78 EFPFWSELQKQAAPKGNLADLGLLPIEKL----RQSLASVG------ARALDHFLAQEPIQKLLK 132
            ....|::.:......|...  |....|.|    .:|:|.:.      .|.....|..|.:.:.|.
Human    80 YAVPWTQKEFDRVTLGYTQ--GFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLN 142

  Fly   133 MSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALVPAA-------CSP 190
            .:    .|||:|.|                 .|.:.......|:.      :||.       |.
Human   143 AT----SFDVVLTD-----------------PVNLCGAVLAKYLS------IPAVFFWRYIPCD- 179

  Fly   191 IDFERDQ----------------PEMSFSVRLGNIRTCIARRKQFIKDHYGG-QEQLVTKYFQLQ 238
            :||:..|                ..|:|..|:.|:...:|  ..:|...:.. ...|.::.||.:
Human   180 LDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLA--LSYICHTFSAPYASLASELFQRE 242

  Fly   239 SSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLE-EARPGAIYV 302
            .|:.:| .|..||.|......:..|:..:..::..||::....|.|....:.::. ....|.:..
Human   243 VSVVDL-VSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVF 306

  Fly   303 QLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVK 367
            .||:  ...::|::|...:........|:::|.....:. ..|..|.::...:||.|:|.||..:
Human   307 SLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRP-SNLANNTILVKWLPQNDLLGHPMTR 368

  Fly   368 AFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLL 432
            ||:|:.....:.|.|...||::.:|||..:..|.:.....|.|:.|....:|:|.|..|:..::.
Human   369 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 433

  Fly   433 ESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAG 497
            :..::..|..:|...:|||:..|..|:|||.:|.||||...||.....::..|.|..|:..|
Human   434 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF--- 495

  Fly   498 IATLVVSLLVA 508
              .|.|.|.||
Human   496 --LLAVVLTVA 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_611694.2	GT1_Gtf-like	25..431	CDD:340817	91/440 (21%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	117/519 (23%)