Protein Alignment Ugt317A1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001286734.1
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 116/534 - (21%)
• Similarity: 215/534 - (40%)
• Gaps: 84/534 - (15%)

  Fly    13 ILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTE---T 74
            :|.|::...:::.|:||:  ..:..|:..||..:.:|..|.|.:.|.|   |..::....|   |
Human    17 LLLLSVQPWAESGKVLVV--PTDGSHWLSMREALRDLHARGHQVVVLT---LEVNMYIKEENFFT 76

  Fly    75 VTAEFPFWSELQKQAAPKGNLADLG-----LLPIEK---LRQSLASVGARALDHFLAQEPIQKLL 131
            :|.....|::.:......|:.....     |:...:   :..:::.:..|:....|..|.:.:.|
Human    77 LTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEALIRHL 141

  Fly   132 KMSYLEFDFDVILVDYFYTEALL--------ALGALHQRP----------------VVGIIST-- 170
            ..:    .|||:|.|.|:..|.:        |:..|...|                :..:::|
Human   142 HAT----SFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNS 202

  Fly   171 DFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYF 235
            |...::..|:..|.|.|.|.:......|..|                            |.::.|
Human   203 DHMTFLQRVKNMLYPLALSYLCHAVSAPYAS----------------------------LASELF 239

  Fly   236 QLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLE-EARPGA 299
            |.:.|:.:| .|..||.|......:..|:..:..::..||::....|.|....:.::. ....|.
Human   240 QREVSVVDL-VSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGI 303

  Fly   300 IYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHP 364
            :...||:  ...::|::|...:........|:::|.....:. ..|..|.::...:||.|:|.||
Human   304 VVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRP-SNLANNTILVKWLPQNDLLGHP 365

  Fly   365 RVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDR 429
            ..:||:|:.....:.|.|...||::.:|||..:..|.:.....|.|:.|....:|:|.|..|:..
Human   366 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 430

  Fly   430 LLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVF 494
            ::.:..::..|..:|...:|||:..|..|:|||.:|.||||...||.....::..|.|..|:..|
Human   431 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 495

  Fly   495 YAGIATLVVSLLVA 508
                 .|.|.|.||
Human   496 -----LLAVVLTVA 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	105/492 (21%)
		UDPGT	25..514	CDD:278624	114/522 (22%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	114/522 (22%)
		egt	<262..508	CDD:223071	64/251 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810