Protein Alignment Ugt317A1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_001286734.1
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 120/527 - (22%)
• Similarity: 223/527 - (42%)
• Gaps: 71/527 - (13%)

  Fly    11 LAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTETV 75
            ||:.|:.:|.     |:||: |. :..|:..|:.:|..|::|.|.|.|....         ...:
Human    18 LALWGMVVGD-----KLLVV-PQ-DGSHWLSMKDIVEVLSDRGHEIVVVVPE---------VNLL 66

  Fly    76 TAEFPFWS-----------ELQKQAAPKGN--LADLGLL--PIEKLRQSLASVGARALDHFL-AQ 124
            ..|..:::           ||:.:....||  .|:...|  |..:.|.::..:|.    :|: .|
Human    67 LKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGL----YFINCQ 127

  Fly   125 EPIQKLLKMSYL-EFDFDVILVDYFYTEALLALGALHQRPVVGIISTD-FGNYMDAVQEALV--- 184
            ..:|....:::. |..||.:     :|:..|..|.: ....:|:.|.. |..:..:::....
Human   128 SLLQDRDTLNFFKESKFDAL-----FTDPALPCGVI-LAEYLGLPSVYLFRGFPCSLEHTFSRSP 186

  Fly   185 -PAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSIPELQA-- 246
             |.:..|..:.:....|:||.|:.|....:.....|.        .|.:||.:|.|::.:...
Human   187 DPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFY--------CLFSKYEELASAVLKRDVDI 243

  Fly   247 ----SQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLE-EARPGAIYVQLGN 306
                .::||.||.....|..|:..:..::..||::.:..|:|....:.::. ....|.:...||:
Human   244 ITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGS 308

  Fly   307 EQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLT 371
              ...::|::|...:........|:::|.....:. ..|..|.::...:||.|:|.||..:||:|
Human   309 --MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRP-SNLANNTILVKWLPQNDLLGHPMTRAFIT 370

  Fly   372 NGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHF 436
            :.....:.|.|...||::.:|||..:..|.:.....|.|:.|....:|:|.|..|:..::.:..:
Human   371 HAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSY 435

  Fly   437 QLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATL 501
            :..|..:|...:|||:..|..|:|||.:|.||||...||.....::..|.|..|:..|     .|
Human   436 KENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF-----LL 495

  Fly   502 VVSLLVA 508
            .|.|.||
Human   496 AVVLTVA 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	107/483 (22%)
		UDPGT	25..514	CDD:278624	116/513 (23%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	120/527 (23%)
		UDPGT	27..523	CDD:278624	116/518 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810