DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	125/525 - (23%)
Similarity:	233/525 - (44%)	Gaps:	51/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLD---N 70
            :||..|.:..|. ....|:|| :| |...|:..::.:::||..:.|.:.|     |..|:.   .
  Rat     9 LLLLHLTIFFGS-GSGGKVLV-WP-VEFSHWLNLKIILSELVKKGHEVVV-----LKPSVSFSYE 65

  Fly    71 VTETVTAEFPFWSELQKQAAPKG-NLADLGLLPIEKLRQSLASVGARAL-DHFLAQEPIQKLLKM 133
            |.:|...||        ::.|.. ::||:.::.::.:.:|:..:..::. .:||.   :|||.:.
  Rat    66 VDKTSAIEF--------ESFPSSYSIADVEVIFMDCVNESIYELPKQSFWGYFLM---LQKLFER 119

  Fly   134 S--YLE-------FD-----------FDVILVDYFYTEALLALGALHQRPVVGIISTDFGNYMDA 178
            :  |.|       |:           |||||.|.| |.....|..:.:.|:|..:....|:..:.
  Rat   120 TSDYSERLCRDAAFNKELMTKLQNSGFDVILADPF-TPCGDLLAEILKIPLVYSLRFFPGSTYEK 183

  Fly   179 VQEAL-VPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSIP 242
            ....| :|.:..||........|:|..|:.::...:.....|.........:|.|:.....:::.
  Rat   184 YSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFDEKKWNELYTEVLGRPTTLS 248

  Fly   243 ELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEA-RPGAIYVQLGN 306
            |..| :..:.|:.::..|..|...:......||||.|..|.||..::.|::.: ..|.:...||:
  Rat   249 ETMA-KADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKPLPKEIEDFVQSSGEHGVVVFSLGS 312

  Fly   307 EQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLT 371
              ..|.|.:|:.:.:.|..:...|.::|. .:.|..|.|..|..:...:||.|:|.||:.:||:|
  Rat   313 --MVGSLTEERANVIAAGLAQIPQKVLWR-FEGKKPETLGSNTRLYKWIPQNDLLGHPKTRAFIT 374

  Fly   372 NGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHF 436
            :|....:.|.|...:|::|:|||..:..|:......|..::|:...:::..|..|:..:..:..:
  Rat   375 HGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLLTALRTVTNDPSY 439

  Fly   437 QLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATL 501
            :.....:|....|:|:..|..|:||:.:|.||||...||..|..:|..|.|..|:..|.......
  Rat   440 KENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSLDVIGFLLACVVT 504

  Fly   502 VVSLL 506
            |:.:|
  Rat   505 VMFIL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	113/481 (23%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	121/509 (24%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	121/509 (24%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	65/240 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810