DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	140/526 - (26%)
Similarity:	231/526 - (43%)	Gaps:	41/526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDN--------VTETVTAEF 79
            |:::||.:||......:......:.|||:|.|.:.|....|..::..|        :.|.:.|
  Fly    30 QSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEIMAA-- 92

  Fly    80 PFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLAQEPIQKLLKMSYLEFDFDVIL 144
             |.:....|.|.:..:..:....:..|..|:           |....::.||....   .||:::
  Fly    93 -FGNADYTQTASQWQMLTMTTQFLNLLTTSI-----------LDDAAVKDLLNSGE---KFDLVI 142

  Fly   145 VDYFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNI 209
            ::...||||..|........:||.|.....::|.:...:.|.:.:|:.......:|.|..|:.|:
  Fly   143 MEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNV 207

  Fly   210 --RTCIARRKQFIKDHYGGQEQLVTKYF-QLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQII 271
              .:.:...|:.:  |...|..|..||| ..:.|:.|:..| .:::||..|..|..|:..:..:|
  Fly   208 FEASVMWLHKRIV--HLPSQRDLYAKYFPTARKSLDEVLDS-FALMLLGQHFSLSYPRPYLPNMI 269

  Fly   272 PAGGLHI---RGPKELPWNVKRFLEEARPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSII 333
            ..||||:   |..:.|...:..|:|::..|.||..:|:......||......|...|::..|.::
  Fly   270 EVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVL 334

  Fly   334 WTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEA 398
            |...| ..|...|.||.|....||.||||||.||.|:|:|.||:..|.|....||||||:|..:.
  Fly   335 WKFED-DQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQH 398

  Fly   399 RNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVN 463
            .|::.|.::|.||..:..:|....|...:..||....:....:..|..|||:...||..|::|..
  Fly   399 LNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTE 463

  Fly   464 YVARHKGGSALRTRGIGISSCQLHLFD---LFVFYAGIATLVVSLLVAL---SFGGFYIWNKKNN 522
            ||.||||...||.....:...|.|..|   |.:....::.|:|.:|:..   .|.......:||.
  Fly   464 YVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNR 528

  Fly   523 SKSTKV 528
            ::::|:
  Fly   529 AEASKL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	129/467 (28%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	136/508 (27%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	127/464 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	132/491 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970