DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	159/544 - (29%)
Similarity:	247/544 - (45%)	Gaps:	63/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTETV 75
            :..|.|.|....|||:||.:||......:..:...:.|||||.|.:.........:.:.|..:..
  Fly     6 IGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVF 70

  Fly    76 TAE-FPFWSELQKQAAPKGNL-------------ADLGLLPIEKLRQSLASVGARALDHFLAQEP 126
            ..: |..:.||..:.:...||             ....:|..:::.::|...|.   ||
  Fly    71 IPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGK---DH------ 126

  Fly   127 IQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGI--ISTDFGNYMDAVQEALVPAACS 189
                         ||:|:|:...::|.....|....|::||  ..||:.  :||:.....|.:.:
  Fly   127 -------------FDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWN--IDALVGNESPLSYT 176

  Fly   190 PIDFERDQPEMSFSVRLGN-IRTCIA-RRKQFIKDHYGGQEQLVTKYFQLQSSIPELQASQL--- 249
            |:........|:|..||.| :.|.:| ...:|:  |...||::..|||...|.  .:|.:.|
  Fly   177 PLATGGLTDRMTFLERLSNFVDTTVAWLNYRFV--HMSEQEKMYAKYFPEASK--RVQLTDLNRN 237

  Fly   250 -SVLLLNSHVPLITPKVSIQQIIPAGGLHI-RGPKELPWNVKRFLE-EARPGAIYVQLGNEQACG 311
             |::|||.|..|..|:..:..:|..||||| ..|..||.:::.|:: ....|.||..||:.....
  Fly   238 FSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSK 302

  Fly   312 QLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLL 376
            .||.::.|.:...|::..|.::|...|.| |.|.|.||.|....||.||||||:||.|:|:|.||
  Fly   303 DLPADRKDLILKTFASLPQRVLWKFEDDK-LPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLL 366

  Fly   377 NLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIR 441
            :..|.|....|:||||.|..:..|:..|.:.|.||.|:...:|.:.|...::.||.|..|....|
  Fly   367 STIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIAR 431

  Fly   442 DVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATLVVSLL 506
            .:|..:||:|:..|.:|::|..||.||||...:|..|..:.....|..|:.....|.|.|:|:::
  Fly   432 QMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAII 496

  Fly   507 VAL-----SFGGFYIWNKKNNSKS 525
            |.:     .||     |.|...||
  Fly   497 VGVLGKLTDFG-----NAKKKLKS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	142/478 (30%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	150/517 (29%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	144/486 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	124/440 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.960