DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	161/526 - (30%)
Similarity:	271/526 - (51%)	Gaps:	22/526 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLG-ESL-DNVT 72
            ||:::.|...::...::||..|....:.||.:...::.||..:.|.:...|...|. |.| .|..
  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYK 75

  Fly    73 ETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLAQEPIQKLLKMSYLE 137
            |.|..::.||.|: |:...|..:.::..||.....:.:..:|....|..|.|..||.::......
  Fly    76 EIVIPQYDFWPEI-KEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKI 139

  Fly   138 FDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSF 202
            ..:|::|.:.|:.|..|.||.|:|.|.:.|.:....|::..:...:.|.:..|..:......|:.
  Fly   140 GKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTL 204

  Fly   203 SVRLGNIRTCIARR--KQFIKDHYGGQEQLVTKYF-QLQSSIPELQASQ--LSVLLLNSHVPLIT 262
            ..|:||:....|..  ::|  .:|.||:.::.|:| :|...:|.::..:  :|.:||||::||.:
  Fly   205 WERIGNVAMSAAEDLVREF--SYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLAS 267

  Fly   263 PKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARPGAIYVQLGNEQACGQLPKEKLDTLFAFFSA 327
            .:.....:||.|||||:.||.||.::::||:.|..||||..||::.....||.|||......|.:
  Fly   268 SRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGS 332

  Fly   328 RKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLP 392
            .||.::|...| ::|..||.||.:|..:||.||||||.||.|:.:|.|...||.:...|||||:|
  Fly   333 LKQRVLWKFED-ESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMP 396

  Fly   393 LF--QHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGAL 455
            ::  ||:..|...:....:||...:  ||.|.|...:..|:....::..|:..|..||||||||:
  Fly   397 VYCDQHQNINQGKSAEYALGLDYRK--VTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAM 459

  Fly   456 ASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATLVVSLLVALSFGGFYIWNKK 520
            .:|::|:|||..|:|...|...|:.:...|.:|.|  :...|:|.:::.::|.:     .|..:.
  Fly   460 DTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLD--IVGLGLAVILLPIVVLI-----LICRRS 517

  Fly   521 NNSKST 526
            :..|||
  Fly   518 SKPKST 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	147/463 (32%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	154/497 (31%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	157/514 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	152/489 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.960