DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	123/545 - (22%)
Similarity:	221/545 - (40%)	Gaps:	73/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESQWNRWILLAILGLALGQIS------QAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEV- 58
            |..:|       |..|.|.|||      :..|:|| :| :...|:..::|::.||..|.|.:.|
  Rat     1 MPGKW-------IFALLLLQISFCLRSAKCGKVLV-WP-MEFSHWMNIKTILDELVQRGHEVTVL 56

  Fly    59 ----YTGHGLGESLDNVTETVTAEFP-----------------FWS-ELQKQAAPKGNLADLGLL 101
                |......:|.|...||    ||                 .|: |||:...          |
  Rat    57 KPSAYYVLDPKKSPDLKFET----FPTSVSKDELEKYFIKLVDAWTYELQRDTC----------L 107

  Fly   102 PIEKLRQSLASVGARALDHF------LAQEPI-QKLLKMSYLEFDFDVILVDYFYTEALLALGAL 159
            ....|.|::       :|.|      :.::.: .|.|.....|..|||:|.|.......|....|
  Rat   108 SFSPLLQNM-------MDEFSDYYLSVCKDAVSNKQLMAKLQESKFDVLLSDPVAACGELIAEVL 165

  Fly   160 HQRPVVGIISTDFGNYMD-AVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDH 223
            | .|.:..:....|:.:: :....::|.:..|:.......:|:|..|:.|:...:.....|...:
  Rat   166 H-IPFLYSLRASPGHKIEKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFDFWFHMFN 229

  Fly   224 YGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNV 288
            ....:...|:.....:::.|.. .:..:.|:.|:..|..|..::..:...|||..:..|.||.::
  Rat   230 AKNWDPFYTEILGRPTTLAETM-GKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQCKPAKPLPKDI 293

  Fly   289 KRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQ 352
            :.|::.: ..|.:...||:  ....:.:||.:.:....:...|.::|. .|.|....|..|..:.
  Rat   294 EDFVQSSGEHGVVVFSLGS--MVSSMTEEKANAVAWALAQIPQKVLWK-FDGKIPATLGPNTRVY 355

  Fly   353 HAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGN 417
            ..:||.|:|.||:.|||:|:|....:.|.|...:|::|:|:|..:..|:...|..|..:.|....
  Rat   356 KWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRT 420

  Fly   418 VTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGIS 482
            ::...|..|:..::....::.....:|....|:|:..|..|:||:.||.|||....||..|..:.
  Rat   421 MSKSDLFNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLP 485

  Fly   483 SCQLHLFDLFVFYAGIATLVVSLLV 507
            ..|.|..|:..|......::.:|.|
  Rat   486 WYQYHSLDVIGFLLACLAVIAALAV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	109/492 (22%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	115/515 (22%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	115/515 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810