DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	124/554 - (22%)
Similarity:	227/554 - (40%)	Gaps:	102/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KILVLFPHVNEGHFAVMRTLVTELANREHTI---------------------EVYT--------G 61
            |:|| :| ....|:..::.::.|||.|.|.:                     |:|:        .
  Rat    25 KVLV-WP-TEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKESSINFEIYSVPLSKSDLE 87

  Fly    62 HGLGESLDNVT---ETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLA 123
            :...:.:|..|   ||::. :.::|::||..   ...:|:    :|.|.::|           :.
  Rat    88 YSFAKWIDEWTRDFETLSI-WTYYSKMQKVF---NEYSDV----VENLCKAL-----------IW 133

  Fly   124 QEPIQKLLKMSYLEFDFDVILVDYFYTEALLALG-------ALHQRPVVGIISTDFGNYMDAVQE 181
            .:.:.|.|:.|    .|||||.|        |:|       .|.:.|:|..:....|...:....
  Rat   134 NKSLMKKLQGS----QFDVILAD--------AVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSG 186

  Fly   182 AL-VPAACSPIDFERDQPEMSFSVRLGNIRTCI--------ARRK---QFIKDHYGGQEQLVTKY 234
            .| :|.:..|:........|:|..|:.|:...:        .:.|   ||..|..|
  Rat   187 GLPLPPSYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLG--------- 242

  Fly   235 FQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEA-RPG 298
              ..:::.|:. .:..:.|:.:...|..|...:......||||.:..|.||..::.|::.: ..|
  Rat   243 --RPTTLTEMM-GKADIWLIRTFWDLEFPHPFLPNFDFVGGLHCKPAKPLPREMEEFVQSSGEHG 304

  Fly   299 AIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAH 363
            .:...||:  ....|.:||.:.:.:..:...|.::|. .|.|..:.|..|..:...:||.|:|.|
  Rat   305 VVVFSLGS--MVKNLTEEKANVVASALAQIPQKVVWR-FDGKKPDTLGSNTRLYKWIPQNDLLGH 366

  Fly   364 PRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVD 428
            |:.|||:.:|....:.|.|...:||:|:|||..:..|:...|..|..::::...::|..|..|:.
  Rat   367 PKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALK 431

  Fly   429 RLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFV 493
            .::.:..::.....:|....|:|:..|..|:||:.||.||||...||:....:|..|.|..|:..
  Rat   432 IVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIG 496

  Fly   494 FYAGIATLVVSLLVALSFGGFYIWNKKNNSKSTK 527
            |.  :..:|..:.:...|..|......|..|..|
  Rat   497 FL--LLCVVGVVFIITKFCLFCCRKTANMGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	113/502 (23%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	120/539 (22%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	123/551 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810