DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	130/568 - (22%)
Similarity:	219/568 - (38%)	Gaps:	112/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESQWNRWILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEV-----YT 60
            |..:|...:||..:.... |.....|:|| :| :...|:..::|::.||..|.|.:.|     |.
  Rat     1 MPGKWISALLLLQISCCF-QSGNCGKVLV-WP-MEFSHWMNIKTILDELVQRGHEVTVLKPSAYY 62

  Fly    61 GHGLGESLDNVTETVTAEFP-----------------FWS-ELQKQAAPKGNLADLGLLPIEKLR 107
            .....:|.|...||    ||                 .|: |||:...          |....|.
  Rat    63 VLDPKKSPDLKFET----FPTSVSKDELENYFIKLVDVWTYELQRDTC----------LSYSPLL 113

  Fly   108 QSLASVGARALDHF------LAQEPI-QKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVV 165
            |::       :|.|      |.::.: .|.|.....|..|||:|.|.......|....||...:.
  Rat   114 QNM-------IDGFSDYYLSLCKDTVSNKQLMAKLQESKFDVLLSDPVAACGELIAEVLHIPFLY 171

  Fly   166 GI-------ISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDH 223
            .:       |....|.:       ::|.:..|:........|:|..|:.|:
  Rat   172 SLRFSPGYKIEKSSGRF-------ILPPSYVPVILSGMGGPMTFIDRVKNM-------------- 215

  Fly   224 YGGQEQLVTKYFQ-------------LQSSI---PELQASQL---SVLLLNSHVPLITPKVSIQQ 269
                  :.|.||.             ..|.|   |...|..:   .:.|:.|:..|..|..::..
  Rat   216 ------ICTLYFDFWFHMFNAKKWDPFYSEILGRPTTLAETMGKAEMWLIRSYWDLEFPHPTLPN 274

  Fly   270 IIPAGGLHIRGPKELPWNVKRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSII 333
            :...|||..|.||.||.:::.|::.: ..|.:...||:  ....:.:||.:.:....:...|.::
  Rat   275 VDYIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGS--MVSSMTEEKANAIAWALAQIPQKVL 337

  Fly   334 WTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEA 398
            |. .|.||...|..|..:...:||.|:|.||:.|||:|:|....:.|.|...:|::|:|:|..:.
  Rat   338 WK-FDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFGEQH 401

  Fly   399 RNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVN 463
            .|:...|..|..:.|....::...|..|:..::....::.....:|....|:|:..|..|:||:.
  Rat   402 DNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKAVFWIE 466

  Fly   464 YVARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATLVVSLLVALSF 511
            :|.||||...||..|..:...|.|..|:..|.. ..:.|:::|...||
  Rat   467 FVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLL-TCSAVIAVLTVKSF 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	116/511 (23%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	125/544 (23%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	125/544 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810