DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	140/575 - (24%)
Similarity:	246/575 - (42%)	Gaps:	105/575 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESQWNRWILLAILGLALGQIS------QAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVY 59
            |..:|       |..|.|.|||      ...|:|| :| ::..|:..::.::.||..|.|.:.|
  Rat     1 MPRKW-------ISALFLLQISYCFKSGHCGKVLV-WP-MDFSHWMNIKIILDELVQRGHEVTV- 55

  Fly    60 TGHGLGES----LDNVTETVTAEFPFWS------ELQKQAAPKGNLADLGLLPIEKLRQSLASVG 114
                |..|    || ..::...:|..:|      |||....   .|.|:....:.:
  Rat    56 ----LKPSAYFFLD-PKKSSDLKFEIFSTSISKDELQNHFI---KLLDVWTYELPR--------- 103

  Fly   115 ARALDHFLAQEPI-QKLL-KMSYL-------------------EFDFDVILVDYFYTEALLALGA 158
                |..|:..|| |.|: :.||.                   |..|||:..|...:...|....
  Rat   104 ----DTCLSYSPILQNLVYEFSYFYLSICKDAVSNKQLMTKLQESKFDVLFADPVASCGDLIAEL 164

  Fly   159 LHQRPVVGIISTDFGNYMD-AVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTC---------I 213
            || .|.:..:|...|:.:: ::.:.::|.:..|:.......:|:|..|:.|: .|         |
  Rat   165 LH-IPFLYSLSFSPGHKLEKSIGKFILPPSYVPVILSGLAGKMTFIDRVKNM-ICMLYFDFWFEI 227

  Fly   214 ARRKQFIKDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHI 278
            .|.|::        :...::.....:::.|.. |::.:.|:.|:..|..|..::..:...||||.
  Rat   228 LRHKEW--------DTFYSEILGRPTTVDETM-SKVEIWLIRSYWDLKFPHPTLPNVDYIGGLHC 283

  Fly   279 RGPKELPWNVKRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTL 342
            :..|.||.:::.|::.: ..|.:...||:  ....:.:||.:.:....:...|.::|. .|.||.
  Rat   284 KPAKPLPKDMEEFVQSSGEHGVVVFSLGS--MVSNMTEEKANAIAWALAQIPQKVLWK-FDGKTP 345

  Fly   343 EGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRL 407
            ..|..|..:...:||.|||.||:.|||:|:|....|.|.|...:|::|:|||..:..|:...|..
  Rat   346 ATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFGDQPDNIAHMVAK 410

  Fly   408 GVGLQLEEGNVTTES-LNW--AVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHK 469
            |..:.|   |:.|.| |::  |::.::....::..:..:|....|:|:..|..|:||:.::.|||
  Rat   411 GAAVSL---NIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVFWIEFIMRHK 472

  Fly   470 GGSALRTRGIGISSCQLHLFDLFVF----YAGIATLVVSLLVALSFGGFYIWNKK 520
            |...||..|..:...|.|..|:..|    :|.||.|.|..|  |....|::..:|
  Rat   473 GAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCL--LFMYRFFVKKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	119/505 (24%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	130/537 (24%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	132/545 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910