DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	560	Identity:	135/560 - (24%)
Similarity:	228/560 - (40%)	Gaps:	105/560 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDN------- 70
            :|..|:| |::||||:::.|.:.|.|..:.:||.:.|..|.|...:....|...:..|
Mouse    10 LLWSAVG-IARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQRY 73

  Fly    71 --VTETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLA--------QE 125
              :..:.|::....|:::...:  |.|..:.|:.|              |||:..        |.
Mouse    74 PGIFNSTTSDAFLQSKMRNIFS--GRLTAVELVDI--------------LDHYTKNCDMMVGNQA 122

  Fly   126 PIQKLLKMSYLEFDFDVILVD-----YFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALVP 185
            .||.|.|..     ||::|||     .|....||.:       ...:.||  |.:..|...|..|
Mouse   123 LIQGLKKEK-----FDLLLVDPNDMCGFVIAHLLGV-------KYAVFST--GLWYPAEVGAPAP 173

  Fly   186 AACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSIPELQASQL- 249
            .|..|.........|:|..|:.|....:..|       .|....::.||.::......|.|..:
Mouse   174 LAYVPEFNSLLTDRMNFLERMKNTGVYLISR-------IGVSFLVLPKYERIMQKYNLLPAKSMY 231

  Fly   250 ------SVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARP-GAIYVQLG-- 305
                  |:.:|.:.|.|..|:.::..::..||:..:....||.:::|::..|:. |.:.|..|
Mouse   232 DLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAG 296

  Fly   306 ----NEQ-------ACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQID 359
                :|.       |.|:||               |.:||.....|. :.|..|..:...:||.|
Mouse   297 VKYLSEDIANKLAGALGRLP---------------QKVIWRFSGTKP-KNLGNNTKLIEWLPQND 345

  Fly   360 ILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLN 424
            :|.|..::|||::|.|.::.|.:...||::|:|||......|......|:|:.||...||...|.
Mouse   346 LLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELY 410

  Fly   425 WAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLF 489
            .|:.:::....::...:.:|...:|:|...:....:|::|:.||.|...||:....||.||..|.
Mouse   411 DALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLL 475

  Fly   490 DL-FVFYAGIATLVVSLLVALSFGGFY-----IWNKKNNS 523
            |: ||...|...|...|.....|  .|     :|:|..:|
Mouse   476 DIAFVLLLGAVLLYFILSYVTKF--IYRKIKSLWSKNEHS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	115/497 (23%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	126/532 (24%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	127/535 (24%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000