DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and ugt-47

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_505595.2	Gene:	ugt-47 / 187570	WormBaseID:	WBGene00011006	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	124/565 - (21%)
Similarity:	220/565 - (38%)	Gaps:	103/565 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLAIL-----GLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLG--- 65
            :|||||     |||.       ||||..|..::.|......:..|||...|.:.:.....||
Worm     8 LLLAILYFFEYGLAY-------KILVFSPATSKSHLISNGRIADELAKAGHNVTLLEIDFLGIVD 65

  Fly    66 --ESLDNVTETVTAEFPFWSELQK-----QAAPKGNLADLGLLPIEKLRQSLASVGARALDHFLA 123
              :|...|.:|: ...|  .::|.     |:..:|.:.|.||..:.|...:..:|.....:.||.
Worm    66 STKSAKLVKKTI-VRVP--KKMQGFKNVIQSFSEGVMEDEGLFELLKGNIAYQTVYNDLCEEFLE 127

  Fly   124 QEPIQKLLKMSYLEFDFDVILVDYFYTEAL--------LALGALHQRPVVGIISTDFGNYMDAVQ 180
            .|.:...||    :.:||.     |:.|.|        .|||.  ||..:......|.:..|...
Worm   128 NEVMFNKLK----DENFDA-----FFAEQLNICGFGYAKALGI--QRKFLISSCPFFSHVYDYTS 181

  Fly   181 EALVPAACSPIDFERD-QPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQ-----S 239
            .   ||..:.:.|..| .||.::..|..|:...|.....|...|     ..:|..|:.:     .
Worm   182 H---PAPYASVPFISDMSPEPTYLERTNNLLRGITINTFFYFSH-----NRLTSIFRKKFGDDFP 238

  Fly   240 SIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHI------RGPKELPWNVKRFLEEARPG 298
            :|.|: ...:.::.|.:...:.....::..::..|||.:      .||.     .:..:::...|
Worm   239 AITEI-VRNVDIIFLATDEIIDFSSPTLPNLVHVGGLGVDDDTTEMGPV-----FEAEMKKGDKG 297

  Fly   299 AIYVQLGNEQACGQLPKEKLDTLFAF--------FSARKQSIIWTCHDVKTLEGLPK--NVMIQH 353
            .||..||.......:.|:.:::....        |..|...     :|..|.:...:  ||.:..
Worm   298 VIYFSLGTIANTSTIDKKVMESFLEIVKKFPDYHFLIRADK-----NDKNTKDKATEISNVFVSD 357

  Fly   354 AVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNV 418
            .:||..||.|||::.|:|:.....|.|..:..||::.:|....:..|.....:.|.|::.::...
Worm   358 WLPQPAILHHPRLRTFITHAGYNGLMEAALAGVPLITIPFMFDQNLNSRAIEKKGWGIRRDKKQF 422

  Fly   419 TTE--SLNWAVDRLLL------ESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALR 475
            .||  ::..|:..:|.      ::|   .:||:   .|::|:||....:....:|.::.|...|.
Worm   423 LTEPNAIEEAIREMLTNPSYTKQAH---RVRDL---MRNKPMGARDRFIKTTEWVIQNGGVHELL 481

  Fly   476 TRGIGISSCQLHLFDLFV--FYAGIATLVVSLLVALSFGGFYIWN 518
            |.|..:|..:.:..|:.|  |:.....::......  |||||.::
Worm   482 TEGRDLSIIKYYNLDIIVPCFFVAFYFIIFPFFKL--FGGFYYYS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	105/502 (21%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	113/538 (21%)
ugt-47	NP_505595.2	UDPGT	23..527	CDD:278624	116/543 (21%)
ugt-47	NP_505595.2	egt	<230..509	CDD:223071	57/295 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910