DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt-43

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	111/555 - (20%)
Similarity:	202/555 - (36%)	Gaps:	123/555 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESQWNRWILLAILGLALGQISQAAKILVLFPH-VN-EGHFAVMRTLVT--ELANREHTIEVYTG- 61
            |..:|..:||.::.:.|...:  ..|:....| :| :.|..||||::.  .:|:|..|..:.:|
Worm    53 EEGYNVTLLLPLIDITLNNTN--IPIVKKIKHRINLDIHPGVMRTIIKMGGMASRRQTWTMGSGI 115

  Fly    62 -------HGLGESLDNVTETVTAEFPFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVGARALD 119
                   |.|.:...|:.:.: ...|                  |||  ::|:.....:|
Worm   116 YGFDGISHLLSDLYSNICDNI-FHMP------------------GLL--DRLKAEKYEMG----- 154

  Fly   120 HFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGI----ISTDFGNYMDAVQ 180
               ..||.          |.....|.|:...:.::::.: |    :|:    |:..|     .|.
Worm   155 ---MSEPF----------FVCGFALFDHLGIDKIISVDS-H----IGLEGPKIAHGF-----PVT 196

  Fly   181 EALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYFQLQSSIPELQ 245
            .:.:|||     |......|||..|..::......|| |.:..:..:...:...::.:|:..||.
Worm   197 SSYLPAA-----FSESSDHMSFVERTRSLYETYLNRK-FARLIHNKEIDAMKGVYKGKSTWEELM 255

  Fly   246 ASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKE---LPWNVKRFLEEARPGAIYVQLGNE 307
            ... :.:..||:..|..|.....:.|..||:.....|.   ||.:....| ..|...:.:..|:.
Worm   256 RLP-AYMFTNSNPILDFPYPRPSKFIEIGGIAADEKKHDEVLPESYDHIL-NLRNRTVLISFGSN 318

  Fly   308 Q---------------ACGQLPKEKLDTLFAFFSARKQSIIWTCHD-----VKTLEGLPKNVMIQ 352
            .               |.|.:|    |..|          ||...:     ||..:...||::..
Worm   319 AKSIFMPDHMRRSLIIALGMMP----DITF----------IWKYENSSIDIVKEFDPTIKNIVQV 369

  Fly   353 HAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGN 417
            ..:||..:||.||:..|:|:|.:.:..|......|.:.:|:|..:.||..:..|.|..|.|.:.|
Worm   370 DWMPQQALLADPRLDLFVTHGGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHGGVLMLRKEN 434

  Fly   418 VT-TESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGI 481
            :. .|.:...:..:|.:..:....:.::...|:.|.......|.:.|:|||....:.:.:..|.:
Worm   435 LEYPEIVIETILSVLNDPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGKPTGIDSNSINV 499

  Fly   482 SSCQLHLFDLFVFYAGIATLVVSLLVALSFGGFYI 516
            .....:..||..|          ||:...|..|.:
Worm   500 DFIAYYYLDLIAF----------LLIVAYFAKFLV 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	98/494 (20%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	105/528 (20%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	66/328 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960