DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and ugt-17

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001122841.1	Gene:	ugt-17 / 179406	WormBaseID:	WBGene00007422	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	113/544 - (20%)
Similarity:	208/544 - (38%)	Gaps:	69/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVY-------TGHGLG 65
            :||.:|:     ..|.:.|:||..|.....|...:..:...|.:..|.:.:.       ..|.:|
Worm     9 FILFSII-----DYSNSYKVLVFNPAFGASHSNFLGKISDILIDAGHDVTMLIPIAMQGKKHLVG 68

  Fly    66 -ESLDNVTETVTAEFPFWSELQKQAAPKGNL--------ADLGLLPIEKLRQSLASVGARALDHF 121
             :.:.|:..  ..:.|...||.||...:..|        :|:.|  ..|:..:.:........|.
Worm    69 SKKVKNIIR--IDQDPRSIELYKQTGAEDVLRKKIWKVESDIAL--FFKMAGNFSKTCGYQCQHV 129

  Fly   122 LAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALG--ALHQRPVVGIISTDFGNYMDAVQ---- 180
            ..|..|.:.||..:.|...         ||:|...|  ......|..||:.|...:||.|:
Worm   130 FQQTEILEKLKNEHFELGI---------TESLFICGYPLFDHLGVKTIINADSVLFMDIVKCTLG 185

  Fly   181 ----EALVPAACSPIDFERDQPEMSFSVRLGN-IRTCIARRKQFIKDHYGGQEQLVTKYFQLQSS 240
                ....||..||:     ..:|:...|:.| |:..|.  ..|.|..:..:..::..|:....:
Worm   186 EPSSSTFYPALISPM-----TDKMTLVERIKNAIQMLIP--VYFSKMRFEEELSMIEPYYNGSKT 243

  Fly   241 IPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKE------LPWNVKRFLEEARPGA 299
            ..|| ...::..::||:..|.....::.:.:..||:.::..|:      ..|:   .|...|...
Worm   244 WEEL-LENVAFNMVNSNRYLDYASPTLPKTVFIGGMQVKTKKQGTPKLNKEWD---DLLNIRKEN 304

  Fly   300 IYVQLGNEQACGQLPKE-KLDTLFAFFSARKQSIIWTC-HDVKTLEGLPKNVMIQHAVPQIDILA 362
            :.|..|:.....::|.| |...|..|.|..:.:.||.. .:..|:.....||.:...:||.|:||
Worm   305 VLVSFGSNAFSSEMPDEFKKSFLDVFASMPEITFIWKYEQENSTIAMHLSNVKMTTWMPQSDLLA 369

  Fly   363 HPRVKAFLTNGDLLNLQEGIMRNVP----ILGLPLFQHEARNMELAVRLGVGLQLEEGNV-TTES 422
            ..|:..|:|:|.|.:..|...:..|    |..:||...:.||..:..|.|..:||::.|: ..:.
Worm   370 DNRLSLFVTHGGLGSSIELAYQGTPAVVNIFKIPLMADQPRNAHMLTRHGGAIQLDKTNLDNPQM 434

  Fly   423 LNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLH 487
            :..|:..:|....:....|.::....|:|.......|...::..:......|::.|..::..|.:
Worm   435 IRDAIKTILDNDSYTENARKLAQILEDQPYTPAEVVLKHCDFAVKFGVLDTLQSEGRKLNVFQFY 499

  Fly   488 LFDLFVFYAGIATLVVSLLVALSF 511
            .:|:.|....:...||..:|...|
Worm   500 SYDILVVVCFLIITVVVFIVLYVF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	102/494 (21%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	109/527 (21%)
ugt-17	NP_001122841.1	egt	1..513	CDD:223071	109/532 (20%)
ugt-17	NP_001122841.1	UDPGT	22..538	CDD:278624	109/526 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960