DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt317A1 and ugt-22

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	116/556 - (20%)
Similarity:	227/556 - (40%)	Gaps:	97/556 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAILGLALGQISQAAKILV---LFPH-------------VNEGH-FAVMRTLV-------TELA 50
            ||.:||..:| :::..|||:   ||.|             .:.|| ..|:..::       |.:.
Worm    10 LLLLLGSFVG-LTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHDLTVLMPVIDFKQENKTAMK 73

  Fly    51 NREHTIEVYTGHGLGESLDNVTETVTAEFPFWSELQKQA------APKGNLADLGLLPIEKLRQS 109
            :.::.|::..|..:.::::.:.:.:|   ..|:......      ||                 :
Worm    74 STKNIIKIQPGQDISKTIETMEKFMT---QLWTTDNSNPLFMVFHAP-----------------A 118

  Fly   110 LASVGARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVVGIISTDFGN 174
            ::::.|......|..:.:.:.|:..    :||:.:.:.|.|.|.....|:..|..|.::|.   :
Worm   119 MSAIFASQCRKVLEDKELIERLRAE----NFDLAITEPFDTCAYALFEAIKIRAHVAVLSC---S 176

  Fly   175 YMDAVQEAL-VPAACS--PIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHYGGQEQLVTKYF- 235
            .:|.|.:|: .|.|.|  |.........|:...|..||...:  ...|:..:.|.::..|.|..
Worm   177 RLDHVSKAIGQPIAPSYVPGTQSTHGERMTIWQRFMNILHFL--MGDFLFSYIGDEDFKVAKEII 239

  Fly   236 ----QLQSSIPELQASQLSVLLLNSHVPLIT-PKVSIQQIIPAGGLHIRGPK---ELP--WNVKR 290
                ..:..:||      :..:..:|:||:. |..:..:|||.||:.::..|   |||  ||.
Worm   240 PGVRSWREVLPE------ASFIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNK-- 296

  Fly   291 FLEEARPGAIYVQLGNEQACGQLPKE-KLDTLFAFFSARKQSIIWTCHDVK-TLEGLPKNVMIQH 353
             :...|...|.|..|:......:|:. |.:.|....|....:.||...:.| ||.....||.:..
Worm   297 -ILGLRKKNILVSFGSNARSADMPEHFKQNVLKVAESMPDVTFIWKYENEKDTLADHLDNVYLGD 360

  Fly   354 AVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEE--- 415
            .:||.::|..||:..|:|:|.|.::.|..:...|.:.:|||..:|||..:..|.|....|.:
Worm   361 WLPQNELLGDPRLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDL 425

  Fly   416 GNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIG 480
            ||  .|::...:.::|....:::....::....::|.....:.:..|.:.|:.....::...|..
Worm   426 GN--AETIRNTIKKVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRH 488

  Fly   481 ISSCQLHLFDLFVFYAGIATLVVSLLVALSFGGFYI 516
            .|..:.:|.|       |.::.:.|::..||..|.:
Worm   489 QSYIEYYLLD-------IISIALVLILTTSFISFQL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	102/503 (20%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	110/537 (20%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	105/529 (20%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	65/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960