Protein Alignment Ugt317A1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_611694.2
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 133/572 - (23%)
• Similarity: 240/572 - (41%)
• Gaps: 102/572 - (17%)

  Fly    10 LLAILGLALGQI--SQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVT 72
            :|.::|..|..:  |:|||||.: ..|...|:.:|..:...|.:..|.:.: ..|..|..:..::
Human     6 VLLLVGFLLPGVLLSEAAKILTI-STVGGSHYLLMDRVSQILQDHGHNVTM-LNHKRGPFMPGLS 68

  Fly    73 ET--VTAEFPFWSELQKQAAPKGNLADLGLLPIEK---------------------------LRQ 108
            ::  ..:.:|....|||       ....||...:|                           |.:
Human    69 DSPASASRYPRILYLQK-------YCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEE 126

  Fly   109 SLASVG------------ARALDHFLAQEPIQKLLKMSYLEFDFDVILVDYF-YTEALLA--LGA 158
            :|...|            |....|||.::.|...||..    :||:::|:.| |...|:|  ||
Human   127 TLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNE----NFDMVIVETFDYCPFLIAEKLG- 186

  Fly   159 LHQRPVVGIISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRT--CIARRKQF-- 219
               :|.|.|:||.||:....:.   :|.:..|:........|.|..|:.|...  ...||:|.
Human   187 ---KPFVAILSTSFGSLEFGLP---IPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRRQQHMQ 245

  Fly   220 ------IKDHYGGQEQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHI 278
                  ||:|:....:.|..:..|::.:          ..:||.......:..:...:..|||..
Human   246 STFDNTIKEHFTEGSRPVLSHLLLKAEL----------WFINSDFAFDFARPLLPNTVYVGGLME 300

  Fly   279 RGPKELPWNVKRFLEE-ARPGAIYVQLGNEQACGQLPK--EKLDTLFAFFSARKQSIIWTC---H 337
            :..|.:|.:::.|:.: ...|.:.|.||:.....|.|:  ::::..||..   .|.:||.|   |
Human   301 KPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEMNNAFAHL---PQGVIWKCQCSH 362

  Fly   338 DVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNME 402
            ..|.:. |..||.|...:||.|:||||.::.|:|:|...::.|.|...||::|:|||..:..||.
Human   363 WPKDVH-LAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMV 426

  Fly   403 L--AVRLGVGLQLEEGNVTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYV 465
            .  |.:.||.:||::  :..|:|...:.:::.:..::......|:..|..||......:.|:::|
Human   427 RVEAKKFGVSIQLKK--LKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHV 489

  Fly   466 ARHKGGSALRTRGIGISSCQLHLFDLFVFYAGIATLVVSLLVALSFGGFYIW 517
            .:..|.:.|:.........:.:|.|:|||..|:.  :.:|.:.....|..:|
Human   490 LQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLT--LGTLWLCGKLLGMAVW 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_611694.2	GT1_Gtf-like	25..431	CDD:340817	111/467 (24%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	122/530 (23%)