DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	545	Identity:	115/545 - (21%)
Similarity:	209/545 - (38%)	Gaps:	90/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESQWNRWILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHG--- 63
            |:.|..|            .|..:|.|      :..|:..::.::.||..|.|.:.|.....
Human   224 ETLWKSW------------DSYYSKAL------DGSHWLNIKIILEELIQRNHNVTVLASSATLF 270

  Fly    64 ---------------LGESLDNVTETVTAEFPFWSELQKQAAPKGNLA---DLGLLPIEKLRQSL 110
                           :.....|:...:......|  :..:..|....|   :||     ||..:.
Human   271 INSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLW--IDHRPTPLTIWAFYKELG-----KLLDTF 328

  Fly   111 ASVGARALDHFLAQEPIQKLLKMSYLEFDFDVILVD----------------YFYTEALLALGAL 159
            ..:..:..|..|....:...|:..    .|||::.|                :.||        |
Human   329 FQINIQLCDGVLKNPKLMARLQKG----GFDVLVADPVTICGDLVALKLGIPFMYT--------L 381

  Fly   160 HQRPVVGIISTDFGNYMDAVQEALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDHY 224
            ...| ...:....|.....|  :.||||.|.:   .||  |:|..|:.|  |.....:.:|...|
Human   382 RFSP-ASTVERHCGKIPAPV--SYVPAALSEL---TDQ--MTFGERIKN--TISYSLQDYIFQSY 436

  Fly   225 GGQ-EQLVTKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNV 288
            .|: ....:|.....:::.|.. .:..:.|:.::.....|:..:......||||.:..|.||..:
Human   437 WGEWNSYYSKILGRPTTLCETM-GKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEM 500

  Fly   289 KRFLEEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQ 352
            :.|::.: :.|.:...||:  ....|.:||.:.:.:..:...|.::|. :..|....|..|..:.
Human   501 EEFIQSSGKNGVVVFSLGS--MVKNLTEEKANLIASALAQIPQKVLWR-YKGKKPATLGNNTQLF 562

  Fly   353 HAVPQIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGN 417
            ..:||.|:|.||:.|||:|:|....:.|.|...||::|:|:|..:..|:......|..:::....
Human   563 DWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNT 627

  Fly   418 VTTESLNWAVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGIS 482
            :|:..|..|:..::.|..::.....:|....|:|:..|..|:||:.:|.||||...||.....::
Human   628 MTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLT 692

  Fly   483 SCQLHLFDLFVFYAGIATLVVSLLV 507
            ..|.|..|:..|.....|..:.|::
Human   693 WFQYHSLDVIGFLLVCVTTAIFLVI 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	106/493 (22%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	111/522 (21%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	110/520 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810