DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	236/554 - (42%)	Gaps:	59/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RWILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEV------------- 58
            ||.:...|.|....:.::..:|| || |:..|:..|..||..|..:.|.|.|
Zfish     9 RWPVTLTLLLVTVPVVESGNVLV-FP-VDVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFS 71

  Fly    59 --YTGHGLGESLDNVTETVTAEFPFWSELQ---KQAAPKGNLADLGLLPIEKLRQSL--ASVGAR 116
              ||...| :|...::|....  ||.|.|.   ::.:..|.|.    |.||..:.||  ..:...
Zfish    72 PHYTSVNL-KSSGGLSEDFIG--PFVSRLMNILREGSTWGRLK----LEIEMWQTSLKMIEIERE 129

  Fly   117 ALDHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPVV-GIISTDFGNYMDAVQ 180
            .:.:.:..:.:.:.||.:    .||:||.|......:: ||...:.|:| .:..|.||....|:
Zfish   130 MITNMIEDQQLMQSLKKA----KFDLILTDPAMYGGVM-LGHYLKLPIVYNVRWTIFGEGHFAI- 188

  Fly   181 EALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQ---FIKDHYGGQEQLVTKYFQLQSSIP 242
             |..|.:..|:........|||..|:.|:...|....|   .|...|..   |..::..     |
Zfish   189 -APSPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNA---LCERFIG-----P 244

  Fly   243 ELQASQL----SVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEEARP-GAIYV 302
            |:....|    .:.|..:......|:.::..|:...|...:..|.||.:::.|::.:.. |.|.:
Zfish   245 EVNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIVM 309

  Fly   303 QLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVK 367
            .||.  ..||||.:..:.:...|:...|.|||. :..|....|..|.::...:||.|:|.||:.:
Zfish   310 SLGT--LIGQLPDDVAEAIAEAFAELPQKIIWR-YKGKRPSALGNNTLVMDWMPQNDLLGHPKTR 371

  Fly   368 AFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNM-ELAVRLGVGLQLEEGNVTTESLNWAVDRLL 431
            ||:.:|....:||.|...|||:|..|...:..|: ::.|| |....::...:..||....|..:|
Zfish   372 AFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVR-GAAKNVDFATMDKESFLKTVKEVL 435

  Fly   432 LESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFD-LFVFY 495
            .:..::..::.:|...:|.|:..|.:|:||:.:|.||||.:.|||....:.....|..| :.|..
Zfish   436 YDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLI 500

  Fly   496 AGIATLVVSLLVALSFGGFYIWNKKNNSKSTKVN 529
            :.::.:::|:...:.:....|..:...:|...:|
Zfish   501 SAVSLIILSIYAVIRYFCCRICMRTTKNKRVSLN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	123/484 (25%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	128/519 (25%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	130/531 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910