DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	548	Identity:	147/548 - (26%)
Similarity:	243/548 - (44%)	Gaps:	86/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVTE 73
            :|:|.: .:|..:|.|.|||| :| |:..|:..|..|:.||..|.|.:.|..........:|.|.
Zfish    67 VLVAFI-WSLPSLSLAGKILV-YP-VDGSHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATH 128

  Fly    74 --TVTAEFPFWSELQ--KQAAP-----------KGNLADLGLLPIEK-----LRQSLASVGARAL 118
              ::|.:....|.|:  |..|.           ||::  ...|.::|     |.:|..|. |..:
Zfish   129 YTSITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSI--WSFLALQKEIITLLEESHRST-AEMV 190

  Fly   119 DHFLAQEPIQKLLKMSYLEFDFDVILVDYFYTEALLALGALHQRPV---VGIISTDFGNYMDAVQ 180
            ...|..|.:.|.||    |..:|::|.|..:...:: |||....|:   |..|:...|::
Zfish   191 RVVLEDEKLIKTLK----ESKYDLMLTDPGFAGGVI-LGAYLGLPMVFNVRWITNAEGHF----- 245

  Fly   181 EALVPAACSPIDF-----ERDQPEMSFSVRLGNIRTCIARRKQFIKDHYG-GQ-----------E 228
             |:.|   ||:.:     .|...:|||:.:|.||.            |:| ||           :
Zfish   246 -AIAP---SPLSYIPTIGSRVTDKMSFANKLKNIM------------HFGIGQYIDHMLTRPLYQ 294

  Fly   229 QLVTKYFQLQSSIPEL-QASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFL 292
            .:::||....:::..| |.:.|  .|:........|:.::..::..||...:..|.||..:.:|:
Zfish   295 GVISKYIDPNTNVYALIQGADL--WLMRVDFVFEFPRPTMPNVVYIGGFQCKPSKPLPDELNKFV 357

  Fly   293 EEA-RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVP 356
            |.: ..|.:.:.||.  ..|.|..:..:.:.:.|:...|.:||. |..:....|..|.::...:|
Zfish   358 ESSGEHGVVIMSLGT--LLGSLVPDISEIVASAFAQLPQKVIWR-HVGEKPSTLGNNTLVVDWLP 419

  Fly   357 QIDILAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRL---GVGLQLEEGNV 418
            |.|:|.||:.|||:|:|....:.|.|...||:|||||...:..|:   :||   ||...|:...:
Zfish   420 QNDLLGHPKTKAFVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNI---IRLEARGVARMLDVATL 481

  Fly   419 TTESLNWAVDRLLLESH-FQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGIS 482
            ..:.|..|:..:|.|.. :|..:|.:|...||.||..|.||:||:.:|.||||.:.|||....:.
Zfish   482 DVDILTQALKDILDEKQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLP 546

  Fly   483 SCQLHLFDLFVFYAGIATLVVSLLVALS 510
            ....|..|:......:.|....||:.:|
Zfish   547 WYSYHCLDVLALIMSLCTAAGLLLILIS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	137/500 (27%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	142/532 (27%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	142/532 (27%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	70/231 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910