DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNJ2 and Irk2

DIOPT Version :9

Sequence 1:	NP_000882.1	Gene:	KCNJ2 / 3759	HGNCID:	6263	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	172/356 - (48%)
Similarity:	235/356 - (66%)	Gaps:	27/356 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    32 NGKSKVHTRQ-QCRS-------------RFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWR 82
            |||.  ..|| .|||             |.|.|:|.|||...::..:..|:|.|::||.||.:||
  Fly    72 NGKP--FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWR 134

Human    83 WMLVIFCLAFVLSWLFFGCVFWLIALLHGDLD-------ASKEGKA-CVSEVNSFTAAFLFSIET 139
            |.|:.|.|:|:||||||..::|||...||||:       ..:.|.| |||.::.||:.|||||||
  Fly   135 WTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIET 199

Human   140 QTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMR 204
            |.|||||.|..:.|||.|:||:.||||.|.:..||:.|.|.|||.:.|:|.:||:||.:|||..|
  Fly   200 QHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQR 264

Human   205 DGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITI 269
            ||.|.||:|||::||||::.|.|||||::::.|.|||.:.....::.:|.|.....:|.:.|:.|
  Fly   265 DGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVI 329

Human   270 VHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEK 334
            .|:|||:||||:|:..|:....|||||||||.||:|..:||.||||:..|||||||::||:...|
  Fly   330 EHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNK 394

Human   335 --HYYKVDYSRFHKTYEVPNTPLCSARDLAE 363
              ..|::||:||::|.:| :|||||||:|.|
  Fly   395 DLQAYEIDYARFNETTQV-DTPLCSARELNE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ2	NP_000882.1	IRK_N	1..47	CDD:400662	8/28 (29%)
		IRK	48..186	CDD:395797	72/145 (50%)
		Selectivity filter. /evidence=ECO:0000250	142..147		4/4 (100%)
		IRK_C	193..366	CDD:407551	88/173 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..427
		PDZ-binding. /evidence=ECO:0000255	425..427
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	163/326 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8489
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880