DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNJ2 and Irk1

DIOPT Version :9

Sequence 1:	NP_000882.1	Gene:	KCNJ2 / 3759	HGNCID:	6263	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001262861.1	Gene:	Irk1 / 42742	FlyBaseID:	FBgn0265042	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	182/381 - (47%)
Similarity:	257/381 - (67%)	Gaps:	18/381 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     2 GSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTR---QQCRSRFVKKDGHCNVQFINVGE 63
            |:..:.:.||:.|....::.:..||:...|.......||   ::.|.|.|.|.|.|||...||.:
  Fly    96 GTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAK 160

Human    64 KGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLD------------AS 116
            :.:|||.|||||.||.:|||.|::|..:||.||.|||.::|:||..|.||:            |:
  Fly   161 RRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVAN 225

Human   117 KEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMA 181
            .....||::|::..:|||:|:|||||||||.|.||:|||.|:|.:..|.|.|..|.||::|.|.|
  Fly   226 ITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFA 290

Human   182 KMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLD 246
            |:::||||.:||:||.||||..|||..|||:|||::||||::|||||||:::.::|.|||.:|..
  Fly   291 KLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFY 355

Human   247 QIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQC 311
            |.::::|.|.|.||:..:.|.||||:||.:||||.||..|:....||:||:|||::|:|.||||.
  Fly   356 QQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQA 420

Human   312 RSSYLANEILWGHRYEPVLF--EEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKK 365
            |||||.:|:|||||:..|:.  :|...|:|||:.|:.||:| :||||||:.|.|.|
  Fly   421 RSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELK 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ2	NP_000882.1	IRK_N	1..47	CDD:400662	10/47 (21%)
		IRK	48..186	CDD:395797	71/149 (48%)
		Selectivity filter. /evidence=ECO:0000250	142..147		4/4 (100%)
		IRK_C	193..366	CDD:407551	95/175 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..427
		PDZ-binding. /evidence=ECO:0000255	425..427
Irk1	NP_001262861.1	IRK	145..477	CDD:279361	171/332 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20249
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8489
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960