DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3732 and EWSR1

DIOPT Version :9

Sequence 1:NP_611692.1 Gene:CG3732 / 37588 FlyBaseID:FBgn0034750 Length:282 Species:Drosophila melanogaster
Sequence 2:XP_011528297.1 Gene:EWSR1 / 2130 HGNCID:3508 Length:670 Species:Homo sapiens


Alignment Length:225 Identity:49/225 - (21%)
Similarity:64/225 - (28%) Gaps:112/225 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GAAGSSGVAS--------PGDWICP-----DY--------DCRHLNFARRLQCNKCDRDRDGSDK 54
            |..||.|..|        .|||.||     |:        .|.:.|||.|.:||:|.     :.|
Human   502 GPRGSRGNPSGGGNVQHRAGDWQCPNPSIGDFCCDVIVCRGCGNQNFAWRTECNQCK-----APK 561

  Fly    55 PE-------------RDRDRDRERERGNGSSSSSSSSSKKKLGTEIGKAAADK-----SRGLFSA 101
            ||             |.|........|.|.........    |...|....|:     .||:   
Human   562 PEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPG----GMFRGGRGGDRGGFRGGRGM--- 619

  Fly   102 EDWQCSKCANVNWARRQTCNMCNAPKFSDVEERTGFGGGYNDRG--------VVEYKDRQDSDSE 158
                                           :|.|||||  .||        ::|          
Human   620 -------------------------------DRGGFGGG--RRGGPGGPPGPLME---------- 641

  Fly   159 YDEFGRRK-------KRKHGEHREDSK-RP 180
              :.|.|:       |...||||::.: ||
Human   642 --QMGGRRGGRGGPGKMDKGEHRQERRDRP 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3732NP_611692.1 ZnF_RBZ 22..46 CDD:197784 13/36 (36%)
RanBP2-type Zn finger 24..45 CDD:275376 11/33 (33%)
zf-RanBP 100..129 CDD:279035 0/28 (0%)
RanBP2-type Zn finger 104..123 CDD:275376 0/18 (0%)
EWSR1XP_011528297.1 RRM <351..>459 CDD:223796
RRM_EWS 362..445 CDD:240977
zf-RanBP 519..561 CDD:279035 14/46 (30%)
RanBP2-type Zn finger 523..557 CDD:275375 11/33 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1995
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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