Protein Alignment Cdk9 and CDK18

DIOPT Version :10

• Sequence 1: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: XP_054192892.1
• Gene: CDK18 / 5129
• HGNCID: 8751
• Length: 574
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 140/408 - (34%)
• Similarity: 200/408 - (49%)
• Gaps: 67/408 - (16%)

  Fly     8 LQQPSGSTPSNVGSSSSRTMSLMEKQKYIEDYDFPYCDESNKYEKVAKIGQGTFGEVFKAREKKG 72
            ||..|...|        :.:|.|.::..:.|..|   .:...|.|:.|:|:||:..|||.|.|.
Human   211 LQMESPDLP--------KPLSRMSRRASLSDIGF---GKLETYVKLDKLGEGTYATVFKGRSKL- 263

  Fly    73 NKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDF 137
            .:..||:|::.:::| ||.|.||:||:.:|:.|||.|:|.|.::..|..:.|        |||::
Human   264 TENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLT--------LVFEY 319

  Fly   138 CEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGL 202
            .:.||...|.:.....|:..:|..|.|||.||.|.|..||||||:|..|:||.:.|.||||||||
Human   320 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGL 384

  Fly   203 ARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQ 267
            |||.|:|    ...|:|.|||||||||::|||...|..|:||||.|||..||.|..|:..|:|.:
Human   385 ARAKSVP----TKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVK 445

  Fly   268 QQLTFISQLCGSFTPDVWPGVEELELYKSIELP-------KNQKRRVKERLRPYVKDQTGCDLLD 325
            ::|..|.:|.|:.|.:.||||.....:::...|       .|...|:         |..|..||.
Human   446 EELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRL---------DTDGIHLLS 501

  Fly   326 KLLTL----------DPKKRIDADTALNHDFFWTDPMPSDLSKMLSQHLQSMFE----YLAQPRR 376
            .||.:          .||.::....|        .|.| .|..::..|   :||    |...||.
Human   502 SLLLVSVLPAGPRERQPKSQVPVPHA--------GPTP-QLLWLVCLH---VFETSPLYSPPPRP 554

  Fly   377 SNQMRNYHQQLTTMNQKP 394
            ...:..:..:......||
Human   555 RGGLHTHPLESVHCEPKP 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	123/326 (38%)
CDK18	XP_054192892.1	Protein Kinases, catalytic domain	236..498	CDD:473864	115/287 (40%)