DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk9 and cdk9

DIOPT Version :9

Sequence 1:	NP_477226.2	Gene:	Cdk9 / 37586	FlyBaseID:	FBgn0019949	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_997756.1	Gene:	cdk9 / 321602	ZFINID:	ZDB-GENE-030131-321	Length:	393	Species:	Danio rerio

Alignment Length:	401	Identity:	283/401 - (70%)
Similarity:	323/401 - (80%)	Gaps:	11/401 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MLQQPSGSTPSNVGSSSSRTMSLMEKQKYIEDYDFPYCDESNKYEKVAKIGQGTFGEVFKAREKK 71
            |.:..:||  |..|....|..::|  .||.:..:||:|||.:||||:||||||||||||||:.::
Zfish     1 MQRDKTGS--SGGGEKPDRETAIM--SKYYDGVEFPFCDEFSKYEKLAKIGQGTFGEVFKAKHRQ 61

  Fly    72 GNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFD 136
            ..|| ||:|||||:||||||||||||||:||||||||||||||||||||||..|.|:.:.|||||
Zfish    62 TGKK-VALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKATQFNRYKGSIYLVFD 125

  Fly   137 FCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFG 201
            ||||||||||||.||||:|.|||:|||.|||||||||.||||||||||||||||:.|:|||||||
Zfish   126 FCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 190

  Fly   202 LARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTE 266
            ||||||:.||...||||||||||||||||||||:|:||||:|:||||||||||||||||||||||
Zfish   191 LARAFSLAKNSQGNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 255

  Fly   267 QQQLTFISQLCGSFTPDVWPGVE-ELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTL 330
            |.|||.|||||||.||:|||||: :.|||:.:||||.|||:||:||:.||||....||:||||.|
Zfish   256 QHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKDPYALDLIDKLLVL 320

  Fly   331 DPKKRIDADTALNHDFFWTDPMPSDLSKMLSQHLQSMFEYLAQPRRSNQMRNYHQQLTTMNQKPQ 395
            ||.:|||:|.||||||||:|||||||..|||.|..|||||||.|||...|   .||....|:.|.
Zfish   321 DPAQRIDSDDALNHDFFWSDPMPSDLKNMLSTHNTSMFEYLAPPRRRGHM---PQQPANQNRNPA 382

  Fly   396 DNSM--IDRVW 404
            ..|.  .|||:
Zfish   383 TTSQSEFDRVF 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	241/310 (78%)
cdk9	NP_997756.1	STKc_CDK9	27..337	CDD:270848	241/310 (78%)
cdk9	NP_997756.1	S_TKc	40..337	CDD:214567	235/297 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595563
Domainoid	1	1.000	483	1.000	Domainoid score	I388
eggNOG	1	0.900	-	-		E1_KOG0669
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55566
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1087
OMA	1	1.010	-	-		QHG48642
OrthoDB	1	1.010	-	-		D344403at33208
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		oto38976
orthoMCL	1	0.900	-	-		OOG6_104394
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X3758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800