DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk9 and cdk9

DIOPT Version :9

Sequence 1:	NP_477226.2	Gene:	Cdk9 / 37586	FlyBaseID:	FBgn0019949	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_595616.1	Gene:	cdk9 / 2540239	PomBaseID:	SPBC32H8.10	Length:	591	Species:	Schizosaccharomyces pombe

Alignment Length:	383	Identity:	155/383 - (40%)
Similarity:	227/383 - (59%)	Gaps:	20/383 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSSRTMSLMEKQKYIEDYDFPYCDESNKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDN 86
            |:.|.:.::.|..::.      |.....|..:.|:|:||||||:|::.:|..|.: |:|::||..
pombe    14 SARRKLDVVPKLHFVG------CSHLTDYHLMEKLGEGTFGEVYKSQRRKDGKVY-ALKRILMHT 71

  Fly    87 EKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNV 151
            |||||||||:|||:||:.:||||::.|.::...:|...:..|.:.|:|..:.:|||:|||.|.:|
pombe    72 EKEGFPITAIREIKILKSIKHENIIPLSDMTVVRADKKHRRRGSIYMVTPYMDHDLSGLLENPSV 136

  Fly   152 KFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKN- 215
            ||:..:||..|:||..|..|:|...|||||:||||:||..|||||:|||||||..:.....:||
pombe   137 KFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEESYANKNP 201

  Fly   216 --------RYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTF 272
                    .||..|||.|||.||||||:|.|...:|||..|||||||:...||:||:::..||..
pombe   202 GLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQGSSDLDQLDK 266

  Fly   273 ISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRID 337
            |.:||||.|....|..|:|...:.:....:..|.::.....:.|:.|  .|...:|||:|.:|:.
pombe   267 IFRLCGSPTQATMPNWEKLPGCEGVRSFPSHPRTLETAFFTFGKEMT--SLCGAILTLNPDERLS 329

  Fly   338 ADTALNHDFFWTDPMPSDLSKMLSQHLQSMFEYLAQPRRSNQMRNYHQQLTTMNQKPQ 395
            |..||.|::|.|.|.|::.|::  |...:..||..:.:|..:..|.|....|.|.|.|
pombe   330 ASMALEHEYFTTPPYPANPSEL--QSYSASHEYDKRRKREQRDANSHAFEQTANGKRQ 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	137/318 (43%)
cdk9	NP_595616.1	STKc_BUR1	27..339	CDD:270849	137/320 (43%)
cdk9	NP_595616.1	S_TKc	36..339	CDD:214567	136/305 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	260	1.000	Domainoid score	I374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55566
Inparanoid	1	1.050	279	1.000	Inparanoid score	I679
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		oto101340
orthoMCL	1	0.900	-	-		OOG6_104394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X3758
TreeFam	1	0.960	-	-
	11	10.850