DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17807 and ALKBH8

DIOPT Version :9

Sequence 1:NP_611690.2 Gene:CG17807 / 37585 FlyBaseID:FBgn0034748 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_001287939.2 Gene:ALKBH8 / 91801 HGNCID:25189 Length:664 Species:Homo sapiens


Alignment Length:684 Identity:284/684 - (41%)
Similarity:380/684 - (55%) Gaps:105/684 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ETQQKVNKA-KKADKKQRRCLAIIKSDCEVSPSAEPTPYLAVLNVGLSNGLT--------EECLL 60
            ::..|::|. ||..:||.:....:.....:...:..|..|.|.|.||.||::        |:|.|
Human     6 QSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGL 70

  Fly    61 TEAAATGGKVIQVVMLPGKSYCFFICASLEDSQLIY---EGMHNISTIGQQGAVAYLSYIRQLPA 122
            .:|         ::|.|.|.|.|....:.|:|:..|   .|...:..:||: ...||:::.    
Human    71 VDA---------LLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQK-ITLYLNFVE---- 121

  Fly   123 LAGKSEWN----KPLPRGLHIIADFVTEEEESTLLRAIG--EDGRTSEVTGSLKHRNVKHFGFEF 181
               |.:|.    :.||.||.::.:.::.|||..||.::.  ||........|||||.|||||:||
Human   122 ---KVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEF 183

  Fly   182 LYGTNNVDPSKPLEQSIPSACDILWPRLNSFASTW-----DWSSPDQLTVNEYEPGHGIPPHVDT 241
            .|..||||..|||...:|..|:       ||...|     ....|||:|:|:||||.|||.|:||
Human   184 HYENNNVDKDKPLSGGLPDICE-------SFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDT 241

  Fly   242 HSAFLDPILSLSLQSDVVMDFRRGDD-QVQVRLPRRSLLIMSGEARYDWTHGIRPKHID------ 299
            ||||.|.|:||||.|::||||:..|. .|.|.|||||||:|:||:||.|||||..:..|      
Human   242 HSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASE 306

  Fly   300 -----VVPSASGGLTTQARGKRTSLTFRRLRKGPCDCSYPALCDTQQTKVPQELHASLAAQAITL 359
                 ::.|..|.||...||.|||.|||::|:.||:||||.:||:|:.:.|.....| ..:|..|
Human   307 SLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPES-DKEASRL 370

  Fly   360 EQQNVHEVYDKIADHFSETRHTPWPQVSEFLDSFEPQSVVLDIGCGNGKYLSCNPLLLSVGCDRA 424
            ||:.||:||::||.|||.|||||||.:.|||.:....|:|.||||||||||..|..|..:||||:
Human   371 EQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRS 435

  Fly   425 QGLLAVGRRKGQNVFRCDCLVVPVRSSSIDGCISIAVIHHLATKERRLAALQEMARVLRPGGRAL 489
            |.|:.:.|.:....|.||.|.|||||.|.|.|||||||||.||.|||:|||||:.|:|||||:||
Human   436 QNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKAL 500

  Fly   490 VYVWAKDQRKNDKKSTYLR--QNKAVNKER----TTEQQQRQKQHQEL----------------- 531
            :||||.:|..|.:||.|||  :|....||.    |:.|:...:|.:::                 
Human   501 IYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQE 565

  Fly   532 ----EQQLSNNNPLPVHTNRTEFQQQDVLVPWKTK-----------------DEQKTTYLRYYHV 575
                .:|:||:. ||||.|||.|..|||||||..|                 .:....:.|||||
Human   566 GGCNSRQVSNSK-LPVHVNRTSFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHV 629

  Fly   576 FEEQELENLVSQVHEVQLIKSYYDQGNHCAIFEK 609
            |.|.|||.....|.:|::::|||||||.|.|.:|
Human   630 FREGELEGACRTVSDVRILQSYYDQGNWCVILQK 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17807NP_611690.2 RRM_ALKBH8 40..119 CDD:240877 25/89 (28%)
2OG-FeII_Oxy 136..322 CDD:304390 95/204 (47%)
Methyltransf_11 400..490 CDD:285453 56/89 (63%)
ALKBH8NP_001287939.2 DUF1891 1..37 CDD:117570 6/30 (20%)
RRM_ALKBH8 42..122 CDD:409865 25/96 (26%)
2OG-FeII_Oxy 152..334 CDD:419693 90/188 (48%)
Alpha-ketoglutarate binding. /evidence=ECO:0000269|PubMed:22065580 227..229 1/1 (100%)
Methyltransf_25 410..497 CDD:404528 54/86 (63%)
Methyltransferase domain 411..664 115/254 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 515..575 11/59 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158255
Domainoid 1 1.000 162 1.000 Domainoid score I4002
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H44488
Inparanoid 1 1.050 478 1.000 Inparanoid score I1490
Isobase 1 0.950 - 0 Normalized mean entropy S1867
OMA 1 1.010 - - QHG58582
OrthoDB 1 1.010 - - D434082at33208
OrthoFinder 1 1.000 - - FOG0001370
OrthoInspector 1 1.000 - - oto90003
orthoMCL 1 0.900 - - OOG6_100549
Panther 1 1.100 - - LDO PTHR13069
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1711
SonicParanoid 1 1.000 - - X865
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.850

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