DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17807 and ALKBH1

DIOPT Version :9

Sequence 1:	NP_611690.2	Gene:	CG17807 / 37585	FlyBaseID:	FBgn0034748	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_006011.2	Gene:	ALKBH1 / 8846	HGNCID:	17911	Length:	389	Species:	Homo sapiens

Alignment Length:	322	Identity:	66/322 - (20%)
Similarity:	111/322 - (34%)	Gaps:	107/322 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AATGGKVIQVVMLPG-----KSYCFFI-----CASLE----------------DSQLIYEGMHNI 102
            ||..|.|..:...||     |.:.|:.     .|.||                .:|.:.:...|:
Human     5 AAAVGSVATLATEPGEDAFRKLFRFYRQSRPGTADLEGVIDFSAAHAARGKGPGAQKVIKSQLNV 69

  Fly   103 STIGQQGAVAYLSYIRQLPALAGKSEWN----KPLPRGLHIIADF-------------------- 143
            |::.:|.  ||.:.::.:      |:|.    |..|..:.|...|
Human    70 SSVSEQN--AYRAGLQPV------SKWQAYGLKGYPGFIFIPNPFLPGYQWHWVKQCLKLYSQKP 126

  Fly   144 --------VTEEEESTLLRAIGEDGRTSEVT----GSL--KHRNVK---HFGFEF-LYGTNNVDP 190
                    :::||...|.....|..|..|.|    .||  |.|.|.   |:.::. .|..::..|
Human   127 NVCNLDKHMSKEETQDLWEQSKEFLRYKEATKRRPRSLLEKLRWVTVGYHYNWDSKKYSADHYTP 191

  Fly   191 SKP----LEQSIPSACDILWPRLNSFASTWDWSSPDQLTVNEYEPGHGIPPHVD----THSAFLD 247
            ...    |.:.:.:||.     ...|.:       :...:|.|.....:..|||    .||   .
Human   192 FPSDLGFLSEQVAAACG-----FEDFRA-------EAGILNYYRLDSTLGIHVDRSELDHS---K 241

  Fly   248 PILSLSL-QSDVVM--DFRRGDDQVQVRLPRRSLLIMSGEARYDWTHGIRPKHIDVVPSASG 306
            |:||.|. ||.:.:  ..:|.:....:.:....::||||.:|. ..|.: |:   |:|:..|
Human   242 PLLSFSFGQSAIFLLGGLQRDEAPTAMFMHSGDIMIMSGFSRL-LNHAV-PR---VLPNPEG 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17807	NP_611690.2	RRM_ALKBH8	40..119	CDD:240877	17/80 (21%)
		2OG-FeII_Oxy	136..322	CDD:304390	45/220 (20%)
		Methyltransf_11	400..490	CDD:285453
ALKBH1	NP_006011.2	tRNA-binding. /evidence=ECO:0000305\|PubMed:27745969	86..389		49/233 (21%)
		alkb	119..289	CDD:129659	39/185 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q6NS38	175..177		0/1 (0%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q96Q83	220..222		1/1 (100%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q96Q83	338..344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810