DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17807 and alkbh8

DIOPT Version :9

Sequence 1:	NP_611690.2	Gene:	CG17807 / 37585	FlyBaseID:	FBgn0034748	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_009290865.1	Gene:	alkbh8 / 556362	ZFINID:	ZDB-GENE-100922-251	Length:	666	Species:	Danio rerio

Alignment Length:	665	Identity:	282/665 - (42%)
Similarity:	385/665 - (57%)	Gaps:	64/665 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ETQQKVNKAKKADKKQRRCL----AIIKSDCEVSPSAEPTPYLAVLNVGLSNGLTEECLLTEAAA 65
            |:.:.|.:.|:..|..||.:    .::|.: :::..:.||.:|.|.|.||.||::.|.|| |...
Zfish     2 ESSRSVRRTKEEKKLLRRQIKASHTLLKHE-DITTVSHPTKHLVVSNGGLGNGVSRESLL-EVLK 64

  Fly    66 TGGKVIQVVMLPGKSYCFFICASLEDSQLIYEGMHNISTIGQ-QGAVAYLSYIRQLPALAGKSEW 129
            .||.|..::..|.|.|.|...:|:|..|..|..::..:...| |....|.||:.::......|
Zfish    65 EGGTVESLLTPPSKPYAFVSYSSIEAGQNAYTLLNGRTLQCQDQTMTLYFSYVVKVDCDRSVS-- 127

  Fly   130 NKPLPRGLHIIADFVTEEEESTLLRAIGEDGRTSEVTG--SLKHRNVKHFGFEFLYGTNNVDPSK 192
             ..||.||.::.|||:.|||..:|:|:.......:||.  :||||.|||:|:||.|..||||..|
Zfish   128 -CALPPGLSVLEDFVSLEEELQILKAVDWTPHADDVTAQKALKHRRVKHYGYEFRYDNNNVDKDK 191

  Fly   193 PLEQSIPSACDILWPRLNSFASTWDWSSPDQLTVNEYEPGHGIPPHVDTHSAFLDPILSLSLQSD 257
            ||...:|..||.|..|  ..|.......|||||||:|:.|.||||||||||.|.|.||||||.:.
Zfish   192 PLPGGLPVECDALLQR--CLAGGHISVLPDQLTVNQYQSGQGIPPHVDTHSPFEDTILSLSLGAK 254

  Fly   258 VVMDFRRGDDQ-VQVRLPRRSLLIMSGEARYDWTHGIRPKHIDVVP-SASGG----------LTT 310
            .||||:..|.: |.|.||.||||:|.||:||.|||||.|:..|||| |.:||          ||.
Zfish   255 TVMDFKHPDGRSVAVVLPERSLLVMKGESRYLWTHGITPRKFDVVPVSETGGSGVMTSDLSNLTL 319

  Fly   311 QARGKRTSLTFRRLRKGPCDCSYPALCDTQQTKVPQELHASLAAQAITLEQQNVHEVYDKIADHF 375
            ..|..|||||||::|..||:|:||::||:|:...|..:..: ...|..||.|.||:||::|:.||
Zfish   320 SRRDTRTSLTFRKIRHTPCNCAYPSVCDSQRPPSPPVVPVA-EGDACRLESQYVHQVYEEISSHF 383

  Fly   376 SETRHTPWPQVSEFLDSFEPQSVVLDIGCGNGKYLSCNPLLLSVGCDRAQGLLAVGRRKGQNVFR 440
            |.|||:|||:|.:||.|..|.|.:.|:||||||||..||.:.:|||||:..|:.:...:|.:.|.
Zfish   384 SSTRHSPWPKVRDFLLSLPPGSFLADVGCGNGKYLGINPAVRAVGCDRSVNLVQICIERGYDAFV 448

  Fly   441 CDCLVVPVRSSSIDGCISIAVIHHLATKERRLAALQEMARVLRPGGRALVYVWAKDQRKNDKKST 505
            .|.|.||:|..|.|.|||||||||.||:|||.||::|:.|:::.|||||:||||.:|..|::||.
Zfish   449 SDALSVPLRRGSCDACISIAVIHHFATQERRRAAVRELIRLIKVGGRALIYVWAMEQEYNNQKSK 513

  Fly   506 YLRQNKAVNKE------RTTEQQQRQKQHQE---------LEQQLSN-NNP-LPVHTNRTEFQQQ 553
            ||::..:.:..      :|.|.:..||:..:         .:..||| ..| :.||||||.|..|
Zfish   514 YLKEEASGSSREGGEELKTEENKAIQKEEHDRNMISDIRCTDDGLSNVTQPKIHVHTNRTAFLSQ 578

  Fly   554 DVLVPWKTKD--------------------EQKTTYLRYYHVFEEQELENLVSQVHEVQLIKSYY 598
            |:||||..|.                    :||..:.||||||::.|||.|...|..|::::||:
Zfish   579 DLLVPWHLKGNMENKKGAASGCADIPVENAKQKPVFHRYYHVFQQGELEELCLGVKGVKVLRSYH 643

  Fly   599 DQGNHCAIFEKLSNN 613
            ||||.|...||...|
Zfish   644 DQGNWCVELEKTHGN 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17807	NP_611690.2	RRM_ALKBH8	40..119	CDD:240877	28/79 (35%)
		2OG-FeII_Oxy	136..322	CDD:304390	102/199 (51%)
		Methyltransf_11	400..490	CDD:285453	48/89 (54%)
alkbh8	XP_009290865.1	RRM_ALKBH8	40..119	CDD:240877	28/79 (35%)
		2OG-FeII_Oxy	130..300	CDD:304390	91/171 (53%)
		Methyltransf_11	409..498	CDD:285453	48/88 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594169
Domainoid	1	1.000	161	1.000	Domainoid score	I4005
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44488
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1457
OMA	1	1.010	-	-		QHG58582
OrthoDB	1	1.010	-	-		D434082at33208
OrthoFinder	1	1.000	-	-		FOG0001370
OrthoInspector	1	1.000	-	-		oto39455
orthoMCL	1	0.900	-	-		OOG6_100549
Panther	1	1.100	-	-	LDO	PTHR13069
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1711
SonicParanoid	1	1.000	-	-		X865
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800