DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17807 and Alkbh5

DIOPT Version :9

Sequence 1:	NP_611690.2	Gene:	CG17807 / 37585	FlyBaseID:	FBgn0034748	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_766531.2	Gene:	Alkbh5 / 268420	MGIID:	2144489	Length:	395	Species:	Mus musculus

Alignment Length:	359	Identity:	75/359 - (20%)
Similarity:	122/359 - (33%)	Gaps:	107/359 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EDSQLIYEGMHNISTIGQQGAVAYLSYIRQLPALAGKSEWNKPLPRGLHIIADFVTEEEESTLLR 154
            |:::.:..|:..|....|.......:.|.::.:.|.|..:|                  |.|:.|
Mouse    81 EEARKVKSGIRQIRLFSQDECSKIEARIDEVVSRAEKGLYN------------------EHTVDR 127

  Fly   155 AIGEDGRTSEVTGSLKHRNVKHFGFEFLYGTNNVDPSKPLEQSIPSACDILWPRLNSFASTWDW- 218
            |              ..||...||..:.||..       |::..|.. :.|:|. .......||
Mouse   128 A--------------PLRNKYFFGEGYTYGAQ-------LQKRGPGQ-ERLYPP-GDVDEIPDWV 169

  Fly   219 ----------------SSPDQLTVNEYEPGHGIPPHVDTHSAFLDPILSLSLQSDVVMDF----- 262
                            ...:...:|:|:||..|..|||....|..||:|:|..||..:.|
Mouse   170 HQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQ 234

  Fly   263 ----RRGDDQVQVRLPRRSLLIMSGEARYDWTHGIRPKHIDVVPSASGGLTTQARGKRTSLTFRR 323
                |..:..:.:.:.|.|:.::||.|..:.||.|||:.|              :.:|..:..|:
Mouse   235 FKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDI--------------KERRAVIILRK 285

  Fly   324 LRKGPCDCSYPALCDTQQTK--VPQELHASLAAQAIT-------LEQQNVHEVYDKIADHFSETR 379
            .|     ...|.|    :||  ....|..|.|:..::       |:.:..|...|..|.|
Mouse   286 TR-----LDAPRL----ETKSLSSSTLPPSYASDRLSGNTRDPALKPKRSHRKADPDAAH----- 336

  Fly   380 HTPWPQVSEFLDSFEPQSVVLDIGCGNGKYLSCN 413
               .|::.|.......:||:|......|.:.|.|
Mouse   337 ---RPRILEMDKEENRRSVLLPTHRRRGSFSSEN 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17807	NP_611690.2	RRM_ALKBH8	40..119	CDD:240877	5/28 (18%)
		2OG-FeII_Oxy	136..322	CDD:304390	45/211 (21%)
		Methyltransf_11	400..490	CDD:285453	4/14 (29%)
Alkbh5	NP_766531.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..83		1/1 (100%)
		2OG-FeII_Oxy	<137..271	CDD:328754	34/142 (24%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q6P6C2	194..196		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..395		18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810