DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17807 and Alkbh2

DIOPT Version :9

Sequence 1:	NP_611690.2	Gene:	CG17807 / 37585	FlyBaseID:	FBgn0034748	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001346869.1	Gene:	Alkbh2 / 231642	MGIID:	2141032	Length:	239	Species:	Mus musculus

Alignment Length:	244	Identity:	49/244 - (20%)
Similarity:	83/244 - (34%)	Gaps:	69/244 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 PALAGKSEWNKPLPRGLHIIADFVT--------EEEESTLLRAIGEDGRTSEVTGSL-------- 169
            ||..|.:..:...|...|:.|:.::        :.|...:.|.:.::  ....||:|
Mouse    20 PAPTGGASGDLKSPDWRHLRAEGLSCDYTVLFGKAEADKIFRELEQE--VEYFTGALAKVQVFGK 82

  Fly   170 ------KHRNVKHFGFEFLYGTNNVDPSKP----LEQSIPSACDILWPRLNSFASTWDWSSPDQL 224
                  |.......|..:.:....:.| ||    ||:.....|::.....|.            :
Mouse    83 WHSVPRKQATYGDAGLTYTFSGLTLTP-KPWVPVLERVRDRVCEVTGQTFNF------------V 134

  Fly   225 TVNEYEPG--HGIPPHVDTHSAFL--DPILSLSLQSDVVMDFRRGDDQ----------VQVRLPR 275
            .||.|:.|  | |..|.|......  .||.|:|..:.....||..|.:          |:::|..
Mouse   135 LVNRYKDGCDH-IGEHRDDERELAPGSPIASVSFGACRDFIFRHKDSRGKRPRRTVEVVRLQLAH 198

  Fly   276 RSLLIMSGEARYDWTHGIRPKHIDVVPSASGGLTTQARGKRTSLTFRRL 324
            .|||:|:......|.|.:..:...:.|             |.:||||::
Mouse   199 GSLLMMNPPTNTHWYHSLPIRKRVLAP-------------RVNLTFRKI 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17807	NP_611690.2	RRM_ALKBH8	40..119	CDD:240877
		2OG-FeII_Oxy	136..322	CDD:304390	43/225 (19%)
		Methyltransf_11	400..490	CDD:285453
Alkbh2	NP_001346869.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..32		3/11 (27%)
		2OG-FeII_Oxy_2	50..232	CDD:372627	41/210 (20%)
		Substrate binding. /evidence=ECO:0000250	80..82		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250	100..102		0/1 (0%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250	137..139		1/1 (100%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250	226..232		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900