DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33143 and igdb-1

DIOPT Version :9

Sequence 1:	NP_001368934.1	Gene:	CG33143 / 37583	FlyBaseID:	FBgn0053143	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_502387.2	Gene:	igdb-1 / 3565301	WormBaseID:	WBGene00011418	Length:	1029	Species:	Caenorhabditis elegans

Alignment Length:	783	Identity:	152/783 - (19%)
Similarity:	268/783 - (34%)	Gaps:	228/783 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TIPATPENITVTFLTPTAVRVSWQTQIDLKAHPIEKYIVTYKPTDD----RVVQDVAGSSEAIVL 77
            |.|:.|.|:|::.||..:|.|.| |:.:..||.:|.|.:..:..:.    |.|::|......:.|
Worm    86 THPSAPGNVTISELTAHSVTVQW-TEPNSNAHLVENYTLFIRKNEHGEAVRTVKNVISPHVELGL 149

  Fly    78 DRLLPSTQYSLVVTA-IWQGKKYRSRGQIKFKTLDLPKNTSQQDFPP------GIYGNSS----- 130
            |   |.::|.|.:.: ...|....|..:: |.||...:       ||      .||.|..
Worm   150 D---PDSEYVLTLQSHSANGTSLPSTAKL-FSTLPTTR-------PPLCTIGEPIYMNDGRVMIC 203

  Fly   131 -------NGARNVTNNASIFGDDVTSTATNTLTHGT--------TRELP--TIRGVEIGIVLIVL 178
                   ||.|     .:..|.|::....:..||.:        .:::|  .:...:..:.|
Worm   204 DAVNPCPNGFR-----CTGAGSDLSYCCPHDGTHSSEEFTSCCKEQKMPESCMSSCQYNMTL--- 260

  Fly   179 MVWAGAIALFFNRWGKIRMLLPYQPDYKHEQLKVPGTGV-CSASGCNGQHSHQCLPRCEGCGIFD 242
                                    |:...|.|   .|.| |::.|    |.|.   ||
Worm   261 ------------------------PESCKENL---NTWVQCASEG----HDHL---RC------- 284

  Fly   243 RCFQYPRRELERDCGCQFALLHKADVESXQPAHREASSAAVSAASSHGHGHSHGTPV---NTYVR 304
             |.|   .|:.:.  ||.|.:|...|.:.: ...|.|......:::|     ...|.   |..|.
Worm   285 -CLQ---EEVSKP--CQTACMHPFTVPADE-CFSEVSKYRTCFSAAH-----QALPAAVRNVEVS 337

  Fly   305 GPSVDNQSI----VGANVL----------ENVDSLDAGDANGDDNIELEGEDVPDKDREDQQLLH 355
            ..|.|:.:|    :.||::          .|:...:...|:....|:||    |:||..
Worm   338 SISKDSATISWEDLEANIIVFRVQLFEKGGNLIKTENSSADIFRFIDLE----PNKDYS------ 392

  Fly   356 RAKEPVHRILPLQAAGAMKQRKFAQQRGILKNSQERTFVEED-EVLEAKKQLILRRRRLFSHYRQ 419
                  .|:..:...|....            |...||..:. ::.|..:.:...:.|:     .
Worm   393 ------VRVTAINFLGEGPP------------SWNATFTTKPAQIYEGDRPVAPEKLRI-----S 434

  Fly   420 YDQWRRRQFSYDP-SYFRPPPLPPRALGCADHQLGAITDANPSANAGRRR--------RQYRRQ- 474
            ::...|...::|| |..|...:..:.:....:.|    |...|:.....|        |..|:.
Worm   435 WNSGPRVNVTWDPVSVRRNAEVVTKPIEYTIYYL----DTEQSSTWTTLRTNQTWVVMRDLRKDA 495

  Fly   475 -YSCADRSREGSRDSRGSSSMQLQLQKYHSMVASDTIHTESSVLNHSNYSEPASFDSSECAHPPL 538
             |.....::|.:|.||.||.:.:..||....:...||..|..  :......|....|..|:.|.:
Worm   496 LYYVYVTAKEDNRTSRSSSIITILAQKDSPGLPEPTIVIEPD--HKDGVFSPGEKISINCSLPNI 558

  Fly   539 HCNSRHI--------HMLAEEHST--SISERCTRSRINSAIFVSSEGRGFDSIEFLRRHGSQSVL 593
               .:|:        |::..:|..  .|.|......:::|....|:..|       |:|.:...|
Worm   559 ---KKHLNIDLTVGSHVVQNDHGALWVILETEADEAMDTATCAVSDTDG-------RQHVAMKHL 613

  Fly   594 CRKAKSAENITDNGRRKSLRPWRTDDESCKQQHLSQDSNDIELKECGGAGGEL-LRLPVIHDGKQ 657
            ..:.|::..:    ::..:|.  .||:|            :|: ||...||.| .::....|||:
Worm   614 VLERKASVTM----KKDKIRV--LDDQS------------VEI-ECIYRGGGLDPKISFEKDGKK 659

  Fly   658 SPTAVTSLLARSAAITTANMIVGSISLEAPPPYMQDDEGDTLSTAALIHSDAAAVVHESQ--DSA 720
            :.....: |.::.|...|...:..:.        |:|.|  .....:..||.:.|...|:  .|.
Worm   660 ASRGFLN-LKKTEAGYVAKWHIRKVK--------QEDAG--FYKCVVTSSDGSRVEASSEVIFST 713

  Fly   721 ETV 723
            ||:
Worm   714 ETL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33143	NP_001368934.1	FN3	19..93	CDD:238020	22/78 (28%)
		DUF4808	165..>230	CDD:374343	9/65 (14%)
		DUF4808	<534..597	CDD:374343	12/72 (17%)
igdb-1	NP_502387.2	DB	1..80	CDD:279948
		FN3	88..178	CDD:238020	25/94 (27%)
		Lustrin_cystein	187..227	CDD:291299	8/44 (18%)
		DB	240..321	CDD:279948	23/131 (18%)
		FN3	328..414	CDD:238020	21/113 (19%)
		FN3	425..518	CDD:238020	19/101 (19%)
		ig	628..701	CDD:278476	21/98 (21%)
		DB	726..809	CDD:279948
		FN3	818..895	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910