DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4329 and Eml4

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_006525218.1	Gene:	Eml4 / 78798	MGIID:	1926048	Length:	999	Species:	Mus musculus

Alignment Length:	832	Identity:	155/832 - (18%)
Similarity:	291/832 - (34%)	Gaps:	186/832 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANKEDVKRASLSNSTVTIRPRLIYGLR-SDVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQR- 64
            |..|.:|: |..|....:.:  ..:||.| .|...|::...|.|::|.:..|:...:|.:..||
Mouse   265 DVDNYDDI-RTELPPEKLKL--EWVYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRH 326

  Fly    65 FLRLPEDTR-----PEVISISSHRKLLAVVERHSKNGR----YISIYELATLKKRRHLELPSNHR 120
            :|...:..|     |:.|.|::.:  :|.|:   |:||    ::.:::..:|.....:.|.:..|
Mouse   327 YLGHTDCVRCLAVHPDKIRIATGQ--IAGVD---KDGRPLQPHVRVWDSVSLTTLHVIGLGTFER 386

  Fly   121 NAEIQQMIFTNDSRSVALITRPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFM 185
            ..........:....:.:|....|..|.:....|.|.:.|.:.|    :.....:..:|.|.|.:
Mouse   387 GVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKSKIAEIKTT----NEVVLAVEFHPTDANTI 447

  Fly   186 AVGGERTLLLMSKSERGFSISNNLKVKYR----VTSMAFLSLDLLMIGTSDDQLI-----LVE-- 239
            ...|:..:...:.|....:....:..||.    |..:|||....::.|.|...::     :||
Mouse   448 ITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTMVEPP 512

  Fly   240 --NGEQKLAQ-----KASDADTVDL------MI------DQEV--FDRDKELQEQRFLPTQAVSL 283
              .|.:.:.|     ||.|.....|      |:      |:::  :|.|..|:.:       :.:
Mouse   513 PGKGPKGVYQINRQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNLERE-------IEV 570

  Fly   284 PDRRVLCMTAFPKGFAYIIFNRAFVFERVSKFKFERKTILTVPTNLYAEHMYQILNLAIDHKQET 348
            ||:                                                |..:....:.:.|.
Mouse   571 PDQ------------------------------------------------YGTIRAVAEGRAEQ 587

  Fly   349 VIVTTSHCQIYVGILIVPETLKTKQLKFEPLGVLIHTGEIIAMSVCAWKPIIMTASRDQTIRIWN 413
            .:|.||...|..|..       ....:.|..|   ||.|:..::...:|.:::|.::|:.:.:||
Mouse   588 FLVGTSRNFILRGTF-------NDGFQIEVQG---HTDELWGLATHPFKDLLLTCAQDRQVCMWN 642

  Fly   414 YETALVELVRKFQVDVNIVELSLTGQMAAIG-FSDQLRITQIFMDDLNIVKTYNFPHCNAVRYSN 477
            .....:|..|......:..:...:|.:.||| .|.:..:......||..:.|......:.:|||.
Mouse   643 SVEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSV 707

  Fly   478 FGHMMAAAYDNNIAITSVYKLDVLIN---------LKGHNGIVLSVAWSRTDKFLISGGAEGAIY 533
            .|.::|....:|.    :|...||.|         ..||:..:..:.||..:|.::|...:..|.
Mouse   708 DGTLLAVGSHDNF----IYLYTVLENGRKYSRYGKCTGHSSYITHLDWSPDNKHIMSNSGDYEIL 768

  Fly   534 LWDIETGARL--QEIVQKGTEYVTISCSTNDPLTIYAGTSIGTIREFQDSTLMREITIPSRTKGS 596
            .||||.|.:|  .....|..::.|.:|       :......|...|..|.|             .
Mouse   769 YWDIENGCKLIRNRSDCKDIDWTTYTC-------VLGFQVFGVWPEGSDGT-------------D 813

  Fly   597 VSDVCLARSDLIMFVADHEGNLFNMQLPFLEAGGGTFTNFRFFDGPVNKLRFSYDGTLLFAISNK 661
            ::.:..:.:..::.|||....:...|.|..:|...:. .:......|..:.|:::.:.|.:...|
Mouse   814 INALVRSHNRRVIAVADDFCKVHLFQYPCSKAKAPSH-KYSAHSSHVTNVSFTHNDSHLISTGGK 877

  Fly   662 GTLAI-WAMDNIEGKVPYMDQDLMRSQEV------------------LIPRSQLNDKIEQIANL- 706
            ....| |.:  :| |:|....:::....|                  |.|...|....|:.:.:
Mouse   878 DMSIIQWKL--VE-KLPVPQNEVITDASVTKTPASSSETARPSNSPPLPPSLPLTGTAEEESRMG 939

  Fly   707 ------ELRLKQQAEEFQYQLSQNEIFDGQQLQEVHRSYCSALEELKELNNE 752
                  |..|:|.||..:.|........|..:.|...|..|..:...||..|
Mouse   940 SSPTLVENSLEQIAEPSEEQSEWGSEDLGVVIDEEPASELSETQGATELPEE 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	7/42 (17%)
		WD40 repeat	173..211	CDD:293791	5/37 (14%)
		WD40 repeat	215..248	CDD:293791	10/46 (22%)
		WD40 repeat	288..324	CDD:293791	0/35 (0%)
		WD40	<328..667	CDD:225201	68/351 (19%)
		WD40 repeat	338..383	CDD:293791	8/44 (18%)
		WD40	384..668	CDD:295369	59/296 (20%)
		WD40 repeat	388..426	CDD:293791	7/37 (19%)
		WD40 repeat	430..466	CDD:293791	8/36 (22%)
		WD40 repeat	470..505	CDD:293791	10/43 (23%)
		WD40 repeat	511..548	CDD:293791	11/38 (29%)
		WD40 repeat	554..576	CDD:293791	3/21 (14%)
		WD40 repeat	597..634	CDD:293791	6/36 (17%)
		WD40 repeat	643..669	CDD:293791	6/26 (23%)
		Apolipoprotein	701..864	CDD:279749	14/59 (24%)
		MSP1_C	784..>1011	CDD:284802
		Ax_dynein_light	<958..1026	CDD:287215
Eml4	XP_006525218.1	HELP	247..318	CDD:367505	14/55 (25%)
		WD40	325..678	CDD:392136	73/426 (17%)
		WD40 repeat	335..383	CDD:293791	11/52 (21%)
		WD40 repeat	388..428	CDD:293791	6/39 (15%)
		WD40 repeat	435..472	CDD:293791	5/36 (14%)
		WD40 repeat	481..529	CDD:293791	10/47 (21%)
		WD40	525..885	CDD:392136	79/449 (18%)
		WD40 repeat	535..572	CDD:293791	6/43 (14%)
		WD40 repeat	577..612	CDD:293791	7/41 (17%)
		WD40 repeat	618..655	CDD:293791	7/36 (19%)
		WD40 repeat	660..695	CDD:293791	7/34 (21%)
		WD40 repeat	701..741	CDD:293791	10/43 (23%)
		WD40 repeat	746..781	CDD:293791	11/34 (32%)
		WD40 repeat	814..851	CDD:293791	6/37 (16%)
		WD40 repeat	859..886	CDD:293791	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910