DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4329 and Cfap57

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_008762314.1	Gene:	Cfap57 / 679641	RGDID:	1585948	Length:	1249	Species:	Rattus norvegicus

Alignment Length:	1194	Identity:	343/1194 - (28%)
Similarity:	627/1194 - (52%)	Gaps:	65/1194 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 STVTIRPRLIYGLRSDVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRFLRLPEDTRPEV-ISIS 80
            |||..:...::||||.|..||.|...:.||:|.......::..|..|:|:...:.::..: :|||
  Rat     2 STVVAQSLHVFGLRSHVTNNIFFFDEQIVIFPSGNHCVKYNLDQKWQKFIAGSDKSQGMLALSIS 66

  Fly    81 SHRKLLAVVERHSKNGRYISIYELATL--KKRRHLELPSNHRNAEIQQ---MIFTNDSRSVALIT 140
            .:|:.||:.|. .::...|:||||:::  :||:.|    |:...::|:   |.|:.||:.:...|
  Rat    67 PNRRYLAISET-VQDKPIITIYELSSIPCRKRKVL----NNFEFQVQKFTSMAFSPDSKYLLTQT 126

  Fly   141 RPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFMAVGGERTLLLMSKSERGFSI 205
            .|||..|:..:.:|...:...:|.|  .:.....::.||.|...:.:.|.....::..:|.....
  Rat   127 SPPESNLVYWLWEKQKVMAVIKADI--QNNPIYQVSINPQDNTQVCITGNGIFKILRFAEGTLKQ 189

  Fly   206 SNNLKVKY-RVTSMAFLSLDLLMIGTSDDQLILVENGEQK-----LAQKASDADTVDLMIDQEVF 264
            :|..:.:. ...:.:::|.|.:::||...:|.|.|:|:|:     :.::.:.:.::|::.:.|
  Rat   190 TNFQRGESPNCLAHSWVSEDRIIVGTDTGKLFLFESGDQRWETNIMVKEPTSSRSLDIIHESE-- 252

  Fly   265 DRDKELQEQRFLP----------------TQAVSLPDRRVLCMTAFPKGFAYIIF-NRAFVFERV 312
                .|.|  |.|                ||.|.||  :|..:.|:.||||.... .|..:||:|
  Rat   253 ----SLVE--FPPPSSPASSIEQMSTTTYTQQVVLP--QVFAIAAYSKGFACSAGPGRVLLFEKV 309

  Fly   313 SKFKFERKT-ILTVPTNLYAEHMYQ-----ILNLAIDHKQETVIVTTSHCQIYVGILIVPETLKT 371
            .:..|.|:: .:.:|.:..:....|     :|.|.....:||::.:||..|:|...:.:.|..|.
  Rat   310 EEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSITMSLTEISKG 374

  Fly   372 KQLKFEPLGVLIHTGEIIAMSVCAWKPIIMTASRDQTIRIWNYETALVELVRKFQVDVNIVELSL 436
            :...||.|...:|:..|..::.|..||:|.|.|.|:::||||||:..:||.:::|.:...|.|..
  Rat   375 EAAHFEYLLYPLHSASITGLATCIRKPLIATCSLDRSVRIWNYESNTLELYKEYQEEAYTVSLHP 439

  Fly   437 TGQMAAIGFSDQLRITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMAAAYDNNIAITSVYKLDVL 501
            :|....:||:|:||:..:.:||:...|.|:...|....:||.||:.||...|.|.|.:...|:.:
  Rat   440 SGHYIVVGFADKLRLMNLLIDDIRSFKEYSVRGCKECAFSNGGHLFAAVNGNVIHIFTTTNLENI 504

  Fly   502 INLKGHNGIVLSVAWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGTEYVTISCSTNDPLTI 566
            .|||||.|.:.|:.|:..|..|||.|.:||:|.|::.||.|..|.|.|...|.:::.|. |...|
  Rat   505 NNLKGHTGKIRSLVWNTDDSKLISAGTDGAVYEWNLSTGKRETECVLKVCSYNSVTISP-DGKVI 568

  Fly   567 YAGTSIGTIREFQDSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLPF-LEAGG 630
            :|..|..|::|..||.::|||........:::   ::.|..::||....|.:..|:.|. |:.
  Rat   569 FAVGSDQTLKEIADSLILREIPAFDVVYTAIT---ISHSGRMIFVGTSVGTIRAMKYPLPLQR-- 628

  Fly   631 GTFTNFRFFDGPVNKLRFSYDGTLLFAISNKGTLAIWAMDNIEGKVPYMDQDLMRSQEVLIPRSQ 695
             .|..::...|||.|:..::|...|..:|..|.|..|.:.:.||:....::::..::|||:.::.
  Rat   629 -EFNEYQAHAGPVTKILLTFDDQFLLTVSEDGCLFTWKVFDKEGRGIKREREVGFAEEVLVTKTD 692

  Fly   696 LNDKIEQIANLELRLKQQAEEFQYQLSQNEIFDGQQLQEVHRSYCSALEELKELNNEIEA-RHTE 759
            :.:|.:.:..|:.|:::...|.:|||...::...::::|:...:...:|.||..|..::. :..:
  Rat   693 MEEKAQIMLELKTRVEELKMENEYQLRLKDMNYSEKIKELTDKFIQEMESLKTKNQVLKTEKEKQ 757

  Fly   760 EMNHITFQINSIREEHRIQLDTLATQYSERMLIEYQKFTNLRENMLELRESYEDKLKNSTGTLQD 824
            :::|.....:.|..:.| :|..|....::::|:||:|:..|:.....::|.||.:|:::..|...
  Rat   758 DISHREHLEDLIERQSR-ELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQ 821

  Fly   825 TVEALENNYKQQLNERKELIRDLMKEMQDKKAEFIEYCREVELENDRNMVSTQTEYENKLTTERN 889
            .:|.|...|:.:|.|:..|:.:..::::.:..||.|..:::|.:.||.:...:|:||.||..|:.
  Rat   822 ALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKE 886

  Fly   890 ETQMWRGKAGVLQKKFESQSREIDNLLEEVEILKEEHHKSQRNIQKQMRNIEDLQKDIADRDYAI 954
            .....:|:.|:::|||.|..:||:....::|:||.|..|.|..|:...::|:.|:::|.:||..|
  Rat   887 SNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKTEQVKLQGVIRSLEKDIQGLKREIQERDETI 951

  Fly   955 NGKEKRIQDLLHKNQELDKYKQVLGHKIAELKAQIEPREFQINDKRKHIIEMEAELEGLNQNNVQ 1019
            ..|||||.||..|||||:|:|.||.:||.|||.||||||.:|...::.|.|||.|||..::.|.|
  Rat   952 QDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEDELERFHKQNTQ 1016

  Fly  1020 LELQLKEMRDKYLSNVAELRTERHRAKASRECLHSICSDIYYVAGEINSAEALKKAVKELFRKHA 1084
            |||.:.|:..|..:...|:|.|:.:.:.....:....:|::.....|.....||:.::.||.|:.
  Rat  1017 LELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVSYIQEPRQLKEKIRALFEKYV 1081

  Fly  1085 SDDELKRFVTLDAEVRDEFMRQRRQIENVLD--RYKSVAEDKSVQKKYDKLFKENVILIEEIEKL 1147
            ...::.....|:::::.|:.|||..:|..|.  :.|.|.|.:..:..|.::.:|||.||:||.:|
  Rat  1082 QRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVVKEGELHRADYVRIMQENVSLIKEINEL 1146

  Fly  1148 NETNKMLRSKVKEDLRRSTKTIHK 1171
            ....|:.||:: .||..:.|...|
  Rat  1147 RRELKLTRSQI-YDLESALKVSKK 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	13/45 (29%)
		WD40 repeat	173..211	CDD:293791	6/37 (16%)
		WD40 repeat	215..248	CDD:293791	9/37 (24%)
		WD40 repeat	288..324	CDD:293791	12/37 (32%)
		WD40	<328..667	CDD:225201	108/344 (31%)
		WD40 repeat	338..383	CDD:293791	13/44 (30%)
		WD40	384..668	CDD:295369	94/284 (33%)
		WD40 repeat	388..426	CDD:293791	16/37 (43%)
		WD40 repeat	430..466	CDD:293791	11/35 (31%)
		WD40 repeat	470..505	CDD:293791	12/34 (35%)
		WD40 repeat	511..548	CDD:293791	15/36 (42%)
		WD40 repeat	554..576	CDD:293791	6/21 (29%)
		WD40 repeat	597..634	CDD:293791	7/37 (19%)
		WD40 repeat	643..669	CDD:293791	8/25 (32%)
		Apolipoprotein	701..864	CDD:279749	35/163 (21%)
		MSP1_C	784..>1011	CDD:284802	82/226 (36%)
		Ax_dynein_light	<958..1026	CDD:287215	39/67 (58%)
Cfap57	XP_008762314.1	WD40	7..471	CDD:225201	126/480 (26%)
		WD40 repeat	62..105	CDD:293791	16/47 (34%)
		WD40 repeat	111..153	CDD:293791	12/43 (28%)
		WD40 repeat	156..193	CDD:293791	6/36 (17%)
		WD40 repeat	201..250	CDD:293791	10/48 (21%)
		WD40 repeat	284..335	CDD:293791	13/50 (26%)
		WD40	325..>670	CDD:225201	109/351 (31%)
		WD40 repeat	340..386	CDD:293791	13/45 (29%)
		WD40	387..665	CDD:295369	94/284 (33%)
		WD40 repeat	392..428	CDD:293791	15/35 (43%)
		WD40 repeat	432..466	CDD:293791	10/33 (30%)
		WD40 repeat	474..508	CDD:293791	11/33 (33%)
		WD40 repeat	514..552	CDD:293791	16/37 (43%)
		WD40 repeat	598..632	CDD:293791	8/39 (21%)
		WD40 repeat	640..669	CDD:293791	8/28 (29%)
		GBP_C	<728..854	CDD:303769	26/126 (21%)
		COG1340	790..1135	CDD:224259	111/344 (32%)
		coiled coil	829..840	CDD:293879	3/10 (30%)
		RILP-like	<886..972	CDD:304877	34/85 (40%)
		Ax_dynein_light	<939..1018	CDD:287215	42/78 (54%)
		eIF-4B	<988..1052	CDD:283846	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H51350
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368770at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010