DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4329 and eml2

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	NP_001025406.1	Gene:	eml2 / 569375	ZFINID:	ZDB-GENE-050706-71	Length:	805	Species:	Danio rerio

Alignment Length:	739	Identity:	139/739 - (18%)
Similarity:	254/739 - (34%)	Gaps:	245/739 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IYGLRS-DVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQR-FLRLPEDTR-----PEVISISSHR 83
            :||.|. |...|::...|.|::|....|:..::..:.:|| :|...:|.:     |::::|::.:
Zfish   216 VYGYRGRDCRSNLYLLPTGEIVYFNASVVVLYNVEEQQQRHYLGHNDDVKCLAIHPDMVTIATGQ 280

  Fly    84 KLLAVVERHSKNGR----YISIYELATLKKRR-----------------------HL---ELPSN 118
                 |...||:|:    ::.:::..:|....                       ||   :..::
Zfish   281 -----VAGTSKDGKALPPHVRVWDSVSLNTLHVIGAGVFDRAVTCVAFSKSNGGAHLCAVDDAND 340

  Fly   119 H--------RNAEIQQMIFTNDSRSVALITRPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECI 175
            |        :..::.::..:||| .:..:..|.|..||:              |...||
Zfish   341 HILSVWDWQKEKQLAEVKCSNDS-VLGAVFHPMEANLIV--------------TCGKSH------ 384

  Fly   176 AGNPNDCNFMAVGGERTLL----LMSKSERGFSISNNLKVKYRVTSMAFLSLDLLMIGTSDDQLI 236
                  .||..|.|. ||.    |..|.|         |.|| |..:||......:.|.|...:.
Zfish   385 ------INFWTVEGS-TLTKRQGLFEKHE---------KPKY-VLCIAFAENGDAITGDSSGNIY 432

  Fly   237 LVENGEQKLAQKASDADTVDLMIDQEVFD----RDKELQEQRFLPTQAVS--LPDRRVLCMTAFP 295
            :...|..::::..|.|.      :..:|.    :|..|          ||  ..||:||
Zfish   433 IWAKGGNRISKVVSGAH------EGGIFSLCVLKDGTL----------VSGGGKDRKVL------ 475

  Fly   296 KGFAYIIFNRAFVFERVSKFKFERKTILTVPTNLYAEHMYQILNLAIDHKQETVIVTTSHCQIYV 360
                            :....:.:|:.:.||     |....:..|| :.||:         :::|
Zfish   476 ----------------LWDHDYRKKSEMEVP-----EAFGPVRTLA-EGKQD---------ELFV 509

  Fly   361 GILIVPETLKTKQLKFEPLGVLI-----HTGEIIAMSVCAWKPIIMTASRDQTIRIWNYETALVE 420
            |      |.|...|:....|.|.     ||.|:..:.|.......:|..:|:.:.:|:..:.|..
Zfish   510 G------TTKNAVLRGSFSGSLTPIVQGHTDELWGLDVHPSTEQFVTCGQDKQVCLWDTCSHLPL 568

  Fly   421 LVRKFQVDVNIVELSLTGQMAAIGF---------SDQLRITQIFMDDLNIVKTYNFPHCNAVRYS 476
            ..:..:.....|....:|.:.|:|.         :|...:..:..|...|:        :.|:||
Zfish   569 WTKAIEDPARSVGFHPSGTVVAVGTMTAKWLVLDTDTRDLVSMHTDGNEII--------SVVKYS 625

  Fly   477 NFG-HMMAAAYDNNIAITSV----YKLDVLINLKGHNGIVLSVAWSRTDKFLISGGAEGAIYLWD 536
            ..| ::...::||.:.|.||    .|...:....||:..|..:.||...:|:::...:..|..|:
Zfish   626 PDGAYLAVGSHDNFVYIYSVTENGKKYSRVGKCTGHSSFVTHLDWSTDSQFIVTNSGDYEILYWE 690

  Fly   537 IETGARL--QEIVQKGTEYVTISCSTNDPLTIYAGTSI-GTIREFQDSTLMREITIPSRTKGSVS 598
            ..:|..:  .:|| :..|:.|.:|        ..|.|: |...:..|.|             .::
Zfish   691 ASSGKHITNNDIV-RNLEWATSTC--------VLGFSVFGIWPDGADGT-------------DIN 733

  Fly   599 DVCLARSDLIMFVADHEGNLFNMQLPFLEAGGGTFTNFRFFDGP-----------------VNKL 646
            .||  ||        |:.||.        |....|.....|..|                 |..:
Zfish   734 AVC--RS--------HDKNLL--------ASADDFGKVHLFSNPCSQPRAPSHIYGGHSSHVTNV 780

  Fly   647 RFSYDGTLLFAISNKGTLAI-WAM 669
            .|.:|.:.|.:...|.|..: |.:
Zfish   781 AFLHDDSHLISTGGKDTSILQWVL 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	8/42 (19%)
		WD40 repeat	173..211	CDD:293791	9/41 (22%)
		WD40 repeat	215..248	CDD:293791	6/32 (19%)
		WD40 repeat	288..324	CDD:293791	3/35 (9%)
		WD40	<328..667	CDD:225201	73/378 (19%)
		WD40 repeat	338..383	CDD:293791	10/44 (23%)
		WD40	384..668	CDD:295369	61/318 (19%)
		WD40 repeat	388..426	CDD:293791	5/37 (14%)
		WD40 repeat	430..466	CDD:293791	7/44 (16%)
		WD40 repeat	470..505	CDD:293791	10/39 (26%)
		WD40 repeat	511..548	CDD:293791	8/38 (21%)
		WD40 repeat	554..576	CDD:293791	5/22 (23%)
		WD40 repeat	597..634	CDD:293791	8/36 (22%)
		WD40 repeat	643..669	CDD:293791	7/26 (27%)
		Apolipoprotein	701..864	CDD:279749
		MSP1_C	784..>1011	CDD:284802
		Ax_dynein_light	<958..1026	CDD:287215
eml2	NP_001025406.1	HELP	175..248	CDD:281450	9/31 (29%)
		WD40	232..697	CDD:225201	106/574 (18%)
		WD40	255..561	CDD:295369	73/407 (18%)
		WD40 repeat	264..310	CDD:293791	7/50 (14%)
		WD40 repeat	319..358	CDD:293791	3/38 (8%)
		WD40 repeat	367..404	CDD:293791	14/63 (22%)
		WD40 repeat	412..448	CDD:293791	6/35 (17%)
		WD40	449..802	CDD:295369	85/459 (19%)
		WD40 repeat	453..518	CDD:293791	21/117 (18%)
		WD40 repeat	537..572	CDD:293791	5/34 (15%)
		WD40 repeat	579..614	CDD:293791	5/34 (15%)
		WD40 repeat	619..659	CDD:293791	10/47 (21%)
		WD40	650..>802	CDD:225201	37/191 (19%)
		WD40 repeat	665..689	CDD:293791	5/23 (22%)
		WD40 repeat	732..769	CDD:293791	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910