DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4329 and Eml1

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_038968474.1	Gene:	Eml1 / 362783	RGDID:	1306374	Length:	831	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	124/704 - (17%)
Similarity:	225/704 - (31%)	Gaps:	221/704 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KEDVKRASLSNS----TVTIRPRLIYGLRS-DVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRF 65
            |:.|...||...    |..::...:||.|. |...|::...|.|.:|.:..|:..::..:..||.
  Rat   218 KDQVDSYSLEAKAELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRH 282

  Fly    66 LRLPED------TRPEVISISSHRKLLAVVERHSKNGR----YISIYELATLKKRRHLELPSNHR 120
            .....|      ..|:.|:|::.:     |...||:|:    ::.|::..||.....:.:....|
  Rat   283 YAGHNDDVKCLAVHPDRITIATGQ-----VAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDR 342

  Fly   121 NAEIQQMIFTNDSRSVALITRPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFM 185
              .:..:.|:..:....|.........::.|.|....  |..|.:..|:........:|.|.|.:
  Rat   343 --AVTCIAFSKSNGGSHLCAVDDSNDHVLSVWDWQRE--ERLADVKCSNEAVFAADFHPTDTNII 403

  Fly   186 AVGGE--------------------------RTLLLMSKSERGFSI----SNNL--------KVK 212
            ...|:                          :.:|.::.||.|.:|    |.|:        ::.
  Rat   404 VTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRIS 468

  Fly   213 YRVT--------SMAFLSLDLLMIGTSDDQLILVENGEQKLAQKASDADTVDLMIDQEVFDRDKE 269
            |.|.        ::..|....|:.|...|:.::..||..:...||                   |
  Rat   469 YAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKA-------------------E 514

  Fly   270 LQEQRFLPTQAVSLPDRRVLCMTAFPKGFAYIIFNRAFVFERVSKFKFERKTILTVPTNLYAEHM 334
            :.|| |.|.:.|:
  Rat   515 IPEQ-FGPIRTVA---------------------------------------------------- 526

  Fly   335 YQILNLAIDHKQETVIVTTSHCQIYVGILIVPETLKTKQLKFEPLGVLIHTGEIIAMSVCAWKPI 399
                    :.|...:::.|:...:..|.|....|..|:.          ||.|:..:::.|.||.
  Rat   527 --------EGKGNVILIGTTRNFVLQGTLTGDFTPITQG----------HTDELWGLAIHASKPQ 573

  Fly   400 IMTASRDQTIRIWNYETALVELVRKFQVDVNIVE-------LSLTGQMAAIG--------FSDQL 449
            .:|...|:...:|       :.|....|...|:|       ...:|.:.|:|        |..:.
  Rat   574 FLTCGHDKHATLW-------DAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTET 631

  Fly   450 RITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMA-AAYDNNIAITSV----YKLDVLINLKGHNG 509
            :       ||..|.|......:.:|||..|:.:| .::||.|.|..|    .|...:....||:.
  Rat   632 K-------DLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSS 689

  Fly   510 IVLSVAWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGT----EYVTISCSTNDPLTIYAGT 570
            .:..:.||...:||:|...:..|..|   ..:..:::|...|    |:.|.:|:....:
  Rat   690 FITHLDWSVNSQFLVSNSGDYEILYW---VPSACKQVVSVETTRDIEWATYTCTLGFHV------ 745

  Fly   571 SIGTIREFQDSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLP 624
             .|...|..|.|             .::.||.|....::...|..|.:.....|
  Rat   746 -FGVWPEGSDGT-------------DINAVCRAHEKKLLSTGDDFGKVHLFSYP 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	6/42 (14%)
		WD40 repeat	173..211	CDD:293791	11/75 (15%)
		WD40 repeat	215..248	CDD:293791	7/40 (18%)
		WD40 repeat	288..324	CDD:293791	0/35 (0%)
		WD40	<328..667	CDD:225201	62/321 (19%)
		WD40 repeat	338..383	CDD:293791	6/44 (14%)
		WD40	384..668	CDD:295369	56/265 (21%)
		WD40 repeat	388..426	CDD:293791	7/37 (19%)
		WD40 repeat	430..466	CDD:293791	10/50 (20%)
		WD40 repeat	470..505	CDD:293791	11/39 (28%)
		WD40 repeat	511..548	CDD:293791	7/36 (19%)
		WD40 repeat	554..576	CDD:293791	3/21 (14%)
		WD40 repeat	597..634	CDD:293791	6/28 (21%)
		WD40 repeat	643..669	CDD:293791
		Apolipoprotein	701..864	CDD:279749
		MSP1_C	784..>1011	CDD:284802
		Ax_dynein_light	<958..1026	CDD:287215
Eml1	XP_038968474.1	TD_EMAP1	22..79	CDD:409268
		HELP	201..274	CDD:397490	14/55 (25%)
		WD40	281..669	CDD:421866	82/500 (16%)
		WD40 repeat	291..339	CDD:293791	10/52 (19%)
		WD40 repeat	344..384	CDD:293791	6/41 (15%)
		WD40 repeat	390..432	CDD:293791	4/41 (10%)
		WD40 repeat	438..473	CDD:293791	9/34 (26%)
		WD40 repeat	479..548	CDD:293791	17/148 (11%)
		WD40	556..830	CDD:421866	56/277 (20%)
		WD40 repeat	563..598	CDD:293791	8/41 (20%)
		WD40 repeat	644..685	CDD:293791	11/40 (28%)
		WD40 repeat	691..715	CDD:293791	6/23 (26%)
		WD40 repeat	758..797	CDD:293791	6/28 (21%)
		WD40 repeat	803..830	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000