DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4329 and EML1

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_005267456.2	Gene:	EML1 / 2009	HGNCID:	3330	Length:	840	Species:	Homo sapiens

Alignment Length:	707	Identity:	127/707 - (17%)
Similarity:	225/707 - (31%)	Gaps:	227/707 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KEDVKRASLSNS----TVTIRPRLIYGLRS-DVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRF 65
            |:.|...||...    |..::...:||.|. |...|::...|.|.:|.:..|:..::..:..||.
Human   227 KDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRH 291

  Fly    66 LRLPED------TRPEVISISSHRKLLAVVERHSKNGR----YISIYELATLKKRRHLELPSNHR 120
            .....|      ..|:.|:|::.:     |...||:|:    ::.|::..||.....:.:....|
Human   292 YAGHNDDVKCLAVHPDRITIATGQ-----VAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDR 351

  Fly   121 NAEIQQMIFTNDSRSVALITRPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFM 185
              .:..:.|:..:....|.........::.|.|....  |..|.:..|:........:|.|.|.:
Human   352 --AVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKE--EKLADVKCSNEAVFAADFHPTDTNII 412

  Fly   186 AVGGE--------------------------RTLLLMSKSERGFSI----SNNL--------KVK 212
            ...|:                          :.:|.::.||.|.:|    |.|:        ::.
Human   413 VTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRIS 477

  Fly   213 YRVTSM---AFLSLDLLMIGT------SDDQLILVENGEQKLAQKASDADTVDLMIDQEVFDRDK 268
            |.|...   ...:|.:|..||      .|.:||......|||                    |..
Human   478 YAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKL--------------------RKT 522

  Fly   269 ELQEQRFLPTQAVSLPDRRVLCMTAFPKGFAYIIFNRAFVFERVSKFKFERKTILTVPTNLYAEH 333
            |:.|| |.|.:.|:
Human   523 EIPEQ-FGPIRTVA--------------------------------------------------- 535

  Fly   334 MYQILNLAIDHKQETVIVTTSHCQIYVGILIVPETLKTKQLKFEPL--GVLIHTGEIIAMSVCAW 396
                     :.|.:.:::.|:...:..|         |....|.|:  |   ||.|:..:::.|.
Human   536 ---------EGKGDVILIGTTRNFVLQG---------TLSGDFTPITQG---HTDELWGLAIHAS 579

  Fly   397 KPIIMTASRDQTIRIWNYETALVELVRKFQVDVNIVE-------LSLTGQMAAIG--------FS 446
            |...:|...|:...:|       :.|....|...|:|       ...:|.:.|:|        |.
Human   580 KSQFLTCGHDKHATLW-------DAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFD 637

  Fly   447 DQLRITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMA-AAYDNNIAITSV----YKLDVLINLKG 506
            .:.:       ||..|.|......:.:|||..|:.:| .::||.|.|..|    .|...:....|
Human   638 TETK-------DLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSG 695

  Fly   507 HNGIVLSVAWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGT----EYVTISCSTNDPLTIY 567
            |:..:..:.||...:||:|...:..|..|   ..:..:::|...|    |:.|.:|:....:
Human   696 HSSFITHLDWSVNSQFLVSNSGDYEILYW---VPSACKQVVSVETTRDIEWATYTCTLGFHV--- 754

  Fly   568 AGTSIGTIREFQDSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLP 624
                .|...|..|.|             .::.||.|....::...|..|.:.....|
Human   755 ----FGVWPEGSDGT-------------DINAVCRAHEKKLLSTGDDFGKVHLFSYP 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	6/42 (14%)
		WD40 repeat	173..211	CDD:293791	11/75 (15%)
		WD40 repeat	215..248	CDD:293791	11/41 (27%)
		WD40 repeat	288..324	CDD:293791	0/35 (0%)
		WD40	<328..667	CDD:225201	62/323 (19%)
		WD40 repeat	338..383	CDD:293791	7/46 (15%)
		WD40	384..668	CDD:295369	55/265 (21%)
		WD40 repeat	388..426	CDD:293791	6/37 (16%)
		WD40 repeat	430..466	CDD:293791	10/50 (20%)
		WD40 repeat	470..505	CDD:293791	11/39 (28%)
		WD40 repeat	511..548	CDD:293791	7/36 (19%)
		WD40 repeat	554..576	CDD:293791	3/21 (14%)
		WD40 repeat	597..634	CDD:293791	6/28 (21%)
		WD40 repeat	643..669	CDD:293791
		Apolipoprotein	701..864	CDD:279749
		MSP1_C	784..>1011	CDD:284802
		Ax_dynein_light	<958..1026	CDD:287215
EML1	XP_005267456.2	HELP	210..283	CDD:281450	14/55 (25%)
		WD40	290..678	CDD:295369	85/503 (17%)
		WD40 repeat	300..348	CDD:293791	10/52 (19%)
		WD40 repeat	353..393	CDD:293791	6/41 (15%)
		WD40 repeat	400..440	CDD:293791	4/39 (10%)
		WD40	428..839	CDD:225201	88/497 (18%)
		WD40 repeat	446..479	CDD:293791	7/32 (22%)
		WD40 repeat	488..526	CDD:293791	12/57 (21%)
		WD40 repeat	532..566	CDD:293791	7/102 (7%)
		WD40	565..839	CDD:295369	56/270 (21%)
		WD40 repeat	571..610	CDD:293791	8/45 (18%)
		WD40 repeat	617..648	CDD:293791	7/37 (19%)
		WD40 repeat	654..694	CDD:293791	11/39 (28%)
		WD40 repeat	767..804	CDD:293791	6/28 (21%)
		WD40 repeat	812..839	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910