DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4329 and Eml2

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_038949419.1	Gene:	Eml2 / 192360	RGDID:	621066	Length:	840	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	127/735 - (17%)
Similarity:	239/735 - (32%)	Gaps:	213/735 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RASLSNSTVTIRPRLIYGLRS-DVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQR-FLRLPEDTR 73
            |:.|.:|.:.:  ..:||.|. |...|::...|.||:|.|..|...:...:.:|| :|...:|.:
  Rat   238 RSELPSSRLKL--DWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIK 300

  Fly    74 -----PEVISISSHRKLLAVVERHSKNGR----YISIYELATLKKRRHLELPSNHRNAEIQQMIF 129
                 |::::|::.:     |...:|.|:    ::.:::..:|.....|.|....|.........
  Rat   301 CLAVHPDMVTIATGQ-----VAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSK 360

  Fly   130 TNDSRSVALITRPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFMAVGGERTLL 194
            :|....:..:....:..|.:....|.|.|::.:.    |:........:|.|.|.:...|:..:.
  Rat   361 SNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKC----SNEAVLVATFHPTDPNLLITCGKSHIY 421

  Fly   195 LMS-----KSERGFSISNNLKVKYRVTSMAFLSLDLLMIGTSDDQLILVENGEQKLAQKASDADT 254
            ..|     .|:|......:.|.|| |..:.||....::.|.|...|.:...|..::.|:...|.
  Rat   422 FWSLEGGNLSKRQGLFEKHEKPKY-VLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAH- 484

  Fly   255 VDLMIDQEVF----------------DRDKELQEQRFLPTQAVSLPDRRVLCMTAFPKGFAYIIF 303
                 |..||                ||...|....:...|.|.:|:           .|.
  Rat   485 -----DGGVFALCALRDGTLVSGGGRDRRVVLWGSDYSKVQEVEVPE-----------DFG---- 529

  Fly   304 NRAFVFERVSKFKFERKTILTVPTNLYAEHMYQILNLAIDHKQETVIVTTSHCQIYVGILIVPET 368
                                  |....||           .:.:|:.|.|:...|.:|
  Rat   530 ----------------------PVRTVAE-----------GRGDTLYVGTTRNSILLG------- 554

  Fly   369 LKTKQLKFEPLGVLIHTG----------EIIAMSVCAWKPIIMTASRDQTIRIWNYETALVELVR 423
                         .:|||          |:..::....:...::..:|:.:.:|:.||......|
  Rat   555 -------------SVHTGFSLLVQGHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSR 606

  Fly   424 KFQVDVNIVELSLTGQMAAIGFSDQLRIT--QIFMD----DLNIVKTYNFPHCNAVRYSNFG-HM 481
            ..:..........:|.:.|:|     .:|  .:.:|    ||..:.|......:.|.:|..| ::
  Rat   607 SIEDPARSAGFHPSGSVLAVG-----TVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYL 666

  Fly   482 MAAAYDNNIAITSV----YKLDVLINLKGHNGIVLSVAWSRTDKFLISGGAEGAIYLWDIETGAR 542
            ...::||.:.:.:|    .|:..|....||:..:..:.|::.....::...:..|..||..|..:
  Rat   667 AVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQ 731

  Fly   543 LQEIVQKGTEYVTISCSTNDPLTIYAGTSIGTIREFQDSTLMREITI------PSRTKGSVSDV- 600
            :                          ||..|:|..|.:|....:..      |....|  :|:
  Rat   732 I--------------------------TSADTVRNVQWATATCVLGFGVFGIWPEGADG--TDIN 768

  Fly   601 CLARSDLIMFVADHEGNLFNMQLPFLEAGGGTFTNFRFFDGP-----------------VNKLRF 648
            .:|||        |:|||.        .....|.....|..|                 |..:.|
  Rat   769 AVARS--------HDGNLL--------VSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAF 817

  Fly   649 SYDGTLLFAISNKGTLAI-W 667
            .:|.:::.....|.|..: |
  Rat   818 LWDDSMVLTTGGKDTSVLQW 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	5/42 (12%)
		WD40 repeat	173..211	CDD:293791	7/42 (17%)
		WD40 repeat	215..248	CDD:293791	7/32 (22%)
		WD40 repeat	288..324	CDD:293791	1/35 (3%)
		WD40	<328..667	CDD:225201	63/384 (16%)
		WD40 repeat	338..383	CDD:293791	5/44 (11%)
		WD40	384..668	CDD:295369	57/330 (17%)
		WD40 repeat	388..426	CDD:293791	5/37 (14%)
		WD40 repeat	430..466	CDD:293791	8/41 (20%)
		WD40 repeat	470..505	CDD:293791	8/39 (21%)
		WD40 repeat	511..548	CDD:293791	5/36 (14%)
		WD40 repeat	554..576	CDD:293791	3/21 (14%)
		WD40 repeat	597..634	CDD:293791	8/37 (22%)
		WD40 repeat	643..669	CDD:293791	6/26 (23%)
		Apolipoprotein	701..864	CDD:279749
		MSP1_C	784..>1011	CDD:284802
		Ax_dynein_light	<958..1026	CDD:287215
Eml2	XP_038949419.1	TD_EMAP2	59..106	CDD:409269
		HELP	210..282	CDD:397490	14/45 (31%)
		WD40	267..688	CDD:225201	86/509 (17%)
		WD40 repeat	300..348	CDD:293791	8/52 (15%)
		WD40 repeat	353..391	CDD:293791	5/37 (14%)
		WD40 repeat	401..438	CDD:293791	7/36 (19%)
		WD40 repeat	447..482	CDD:293791	7/34 (21%)
		WD40 repeat	488..529	CDD:293791	8/51 (16%)
		WD40 repeat	532..566	CDD:293791	10/64 (16%)
		WD40	564..838	CDD:421866	54/323 (17%)
		WD40 repeat	572..607	CDD:293791	4/34 (12%)
		WD40 repeat	614..649	CDD:293791	7/39 (18%)
		WD40 repeat	654..694	CDD:293791	8/39 (21%)
		WD40 repeat	700..724	CDD:293791	2/23 (9%)
		WD40 repeat	767..804	CDD:293791	10/52 (19%)
		WD40 repeat	812..839	CDD:293791	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910