DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4329 and CFAP57

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	NP_001182760.2	Gene:	CFAP57 / 149465	HGNCID:	26485	Length:	1283	Species:	Homo sapiens

Alignment Length:	1231	Identity:	341/1231 - (27%)
Similarity:	619/1231 - (50%)	Gaps:	105/1231 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 STVTIRPRLIYGLRSDVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRFLRLPEDTRPEV-ISIS 80
            |.|..:...::||||.|..||.:...:.:|:|.......::..|..|:|:...|.::..: :|||
Human     2 SAVVAQTLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSIS 66

  Fly    81 SHRKLLAVVERHSKNGRYISIYELATL--KKRRHLELPSNHRNAEIQQ---MIFTNDSRSVALIT 140
            .:|:.||:.|...:... |:||||:::  :||:.|    |:.:.::|:   |.|:.||:.:...|
Human    67 PNRRYLAISETVQEKPA-ITIYELSSIPCRKRKVL----NNFDFQVQKFISMAFSPDSKYLLAQT 126

  Fly   141 RPPEETLIMLVLDKTSTVIEGRATIPGSHGGAECIAGNPNDCNFMAVGGERTLLLMSKSE---RG 202
            .|||..|:..:.:|...:...|  |...:.....::.:|.|...:.|.|.....|:..:|   :.
Human   127 SPPESNLVYWLWEKQKVMAIVR--IDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTLKQ 189

  Fly   203 FSISNNLKVKYRVTSMAFLSLDLLMIGTSDDQLILVENGEQK------LAQKASDADTVDLMIDQ 261
            .|........|  .:..:::.|.:::||...:|.|.|:|:|:      :.:..:.:.::|::.:.
Human   190 TSFQRGEPQNY--LAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLDVIQES 252

  Fly   262 EVFDRDKELQEQRFLPTQA----------------VSLPDRRVLCMTAFPKGFAYIIF-NRAFVF 309
            |      .|.|  |.|..:                :|:|  :|..:.|:.||||.... .|..:|
Human   253 E------SLIE--FPPVSSPLPSYEQMVAASSHSQMSMP--QVFAIAAYSKGFACSAGPGRVLLF 307

  Fly   310 ERVSKFKFERKT-ILTVPTNLYAEHMYQ-----ILNLAIDHKQETVIVTTSHCQIYVGILIVPET 368
            |::.:..|.|:: .:.:|.:..:....|     :|.|.....:||::.:||..|:|...:.:.|.
Human   308 EKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSITMSLTEI 372

  Fly   369 LKTKQLKFEPLGVLIHTGEIIAMSVCAWKPIIMTASRDQTIRIWNYETALVELVRKFQVDVNIVE 433
            .|.:...||.|...:|:..|..::.|..||:|.|.|.|::||:|||||..:||.:::|.:...:.
Human   373 SKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSIS 437

  Fly   434 LSLTGQMAAIGFSDQLRITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMAAAYDNNIAITSVYKL 498
            |..:|....:||:|:||:..:.:||:...|.|:...|....:||.||:.||...|.|.:.:...|
Human   438 LHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSL 502

  Fly   499 DVLINLKGHNGIVLSVAWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGTEY--VTISCSTN 561
            :.:.:||||.|.:.|:.|:..|..|||||.:||:|.|::.||.|..|.|.|...|  ||:|   .
Human   503 ENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVS---P 564

  Fly   562 DPLTIYAGTSIGTIREFQDSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLPF- 625
            |...|:|..|..|::|..||.::|||   |....:.:.:.::.|..:|||....|.:..|:.|.
Human   565 DAKIIFAVGSDHTLKEIADSLILREI---SAFDVTYTAIVISHSGRMMFVGTSVGTIRAMKYPLP 626

  Fly   626 LEAGGGTFTNFRFFDGPVNKLRFSYDGTLLFAISNKGTLAIWAMDNIEGKVPYMDQDLMRSQEVL 690
            |:.   .|..::...||:.|:..::|...|...:..|.|..|.:.:.:|:....::::..::|||
Human   627 LQK---EFNEYQAHAGPITKMLLTFDDQFLLTAAEDGCLFTWKVFDKDGRGIKREREVGFAEEVL 688

  Fly   691 IPRSQLNDKIEQIANLELRLKQQAEEFQYQLSQNEIFDGQQLQEVHRSYCSALEELKELNNEIEA 755
            :.::.:.:|.:.:..|:.|:::...|.:|||...::...::::|:...:...:|.||..|..:..
Human   689 VTKTDMEEKAQVMLELKTRVEELKMENEYQLRLKDMNYSEKIKELTDKFIQEMESLKTKNQVLRT 753

  Fly   756 RHTEEMNHITFQINSIREEHRIQLDTLATQYSERMLIEYQKFTNLRENMLELRESYEDKLKNSTG 820
            ...::..:....|..:.::...:|..:....::::|:||:|:..|:.....::|.||.:|:::..
Human   754 EKEKQDVYHHEHIEDLLDKQSRELQDMECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDE 818

  Fly   821 TLQDTVEALENNYKQQLNERKELIRDLMKEMQDKKAEFIEYCREVELENDRNMVSTQTEYENKLT 885
            |....:|.|...|:.:|.|:..|:.:..::::.:..||.|..:::|.:.||.:...:|:||.||.
Human   819 TKSQALEELTEFYEAKLQEKTTLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYEKKLR 883

  Fly   886 TERNETQMWRGKAGVLQKKFESQSREIDNLLEEVEILKEEHHKSQRNIQKQMRNIEDLQKDIADR 950
            .|:......:|:.|:::|||.|..:||:....::|.||.|..|.|..|:...::|:.|:::|.:|
Human   884 DEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIETLKGEQMKLQGVIKSLEKDIQGLKREIQER 948

  Fly   951 DYAINGKEKRIQDLLHKNQELDKYKQVLGHKIAELKAQIEPREFQI---------NDK------- 999
            |..|..|||||.||..|||||.|:|.||.:||.|||.||||||.:|         ||.
Human   949 DETIQDKEKRIYDLKKKNQELGKFKFVLDYKIKELKKQIEPRENEIRVMKEQIQENDPILKWPQR 1013

  Fly  1000 ------------RKHII-----EMEAELEGLNQNNVQLELQLKEMRDKYLSNVAELRTERHRAKA 1047
                        ||.::     :||||||..::.|.||||.:.|:..|..:...|:|.||.:.:.
Human  1014 VEIHLYNFRKQVRKVLLWGTLPQMEAELENFHKQNTQLELNITELWQKLRATDQEMRRERQKERD 1078

  Fly  1048 SRECLHSICSDIYYVAGEINSAEALKKAVKELFRKHASDDELKRFVTLDAEVRDEFMRQRRQIEN 1112
            ....:....:|::.....|.....||:.|:.||.|:....::.....|:.:::.|:.|||..:|.
Human  1079 LEALVKRFKTDLHNCVAYIQEPRLLKEKVRGLFEKYVQRADMVEIAGLNTDLQQEYTRQREHLER 1143

  Fly  1113 VLD--RYKSVAEDKSVQKKYDKLFKENVILIEEIEKLNETNKMLRSKVKEDLRRSTKTIHK 1171
            .|.  :.|.|.|.:..:..|.::.:|||.||:||.:|....|..||:| .||..:.|...|
Human  1144 NLATLKKKVVKEGELHRTDYVRIMQENVSLIKEINELRRELKFTRSQV-YDLEAALKLTKK 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	13/45 (29%)
		WD40 repeat	173..211	CDD:293791	7/40 (18%)
		WD40 repeat	215..248	CDD:293791	8/38 (21%)
		WD40 repeat	288..324	CDD:293791	11/37 (30%)
		WD40	<328..667	CDD:225201	109/346 (32%)
		WD40 repeat	338..383	CDD:293791	13/44 (30%)
		WD40	384..668	CDD:295369	95/286 (33%)
		WD40 repeat	388..426	CDD:293791	17/37 (46%)
		WD40 repeat	430..466	CDD:293791	10/35 (29%)
		WD40 repeat	470..505	CDD:293791	10/34 (29%)
		WD40 repeat	511..548	CDD:293791	16/36 (44%)
		WD40 repeat	554..576	CDD:293791	8/21 (38%)
		WD40 repeat	597..634	CDD:293791	8/37 (22%)
		WD40 repeat	643..669	CDD:293791	6/25 (24%)
		Apolipoprotein	701..864	CDD:279749	32/162 (20%)
		MSP1_C	784..>1011	CDD:284802	85/259 (33%)
		Ax_dynein_light	<958..1026	CDD:287215	42/100 (42%)
CFAP57	NP_001182760.2	WD40	26..452	CDD:295369	108/444 (24%)
		WD40	<29..256	CDD:225201	53/241 (22%)
		WD40 repeat	61..104	CDD:293791	16/47 (34%)
		WD40 repeat	111..148	CDD:293791	10/36 (28%)
		WD40 repeat	156..191	CDD:293791	6/34 (18%)
		WD40 repeat	198..223	CDD:293791	5/26 (19%)
		WD40 repeat	285..336	CDD:293791	12/50 (24%)
		WD40	<335..670	CDD:225201	110/343 (32%)
		WD40 repeat	341..387	CDD:293791	13/45 (29%)
		WD40	388..666	CDD:295369	95/286 (33%)
		WD40 repeat	393..429	CDD:293791	16/35 (46%)
		WD40 repeat	433..467	CDD:293791	9/33 (27%)
		WD40 repeat	475..509	CDD:293791	9/33 (27%)
		WD40 repeat	515..553	CDD:293791	17/37 (46%)
		WD40 repeat	600..635	CDD:293791	9/37 (24%)
		WD40 repeat	643..670	CDD:293791	6/26 (23%)
		Taxilin	728..1000	CDD:286771	84/271 (31%)
		iSH2_PI3K_IA_R	792..909	CDD:304922	32/116 (28%)
		RILP-like	<887..973	CDD:304877	34/85 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154012
Domainoid	1	1.000	299	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_28M22
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51350
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1426
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56435
OrthoDB	1	1.010	-	-		D368770at33208
OrthoFinder	1	1.000	-	-		FOG0007926
OrthoInspector	1	1.000	-	-		oto91140
orthoMCL	1	0.900	-	-		OOG6_102663
Panther	1	1.100	-	-	LDO	PTHR32215
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5807
SonicParanoid	1	1.000	-	-		X5878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800