DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4329 and cfap57

DIOPT Version :9

Sequence 1:	NP_611687.1	Gene:	CG4329 / 37582	FlyBaseID:	FBgn0034745	Length:	1171	Species:	Drosophila melanogaster
Sequence 2:	XP_002931652.2	Gene:	cfap57 / 100496984	XenbaseID:	XB-GENE-6032538	Length:	1226	Species:	Xenopus tropicalis

Alignment Length:	1176	Identity:	341/1176 - (28%)
Similarity:	604/1176 - (51%)	Gaps:	66/1176 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 STVTIRPRLIYGLRSDVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRFLRLPEDTR-PEVISIS 80
            |.:..:...|:||||.|..||.:...:.:|:|.......::..|..|:|:...|.:: .:.::||
Frog     2 SVIVAQSHYIFGLRSPVTNNIFYFDEQTIIFPSGNNCVKYNVDQKWQKFIPGSEKSQGMQALAIS 66

  Fly    81 SHRKLLAVVERHSKNGRYISIYELATL--KKRRHLELP--SNHRNAEIQQMIFTNDSRSVALITR 141
            .:|:.||:.|:..:... ::||:||::  |||:.|..|  :.|   |...:.|:.||:.:...:.
Frog    67 PNRRYLAMSEKGLEKAT-VTIYDLASVPFKKRKVLSAPDLTAH---EFVSIAFSPDSKYLVAQSG 127

  Fly   142 PPEETLIMLVLDKTSTVIEGRATI-PGSHGG-AECIAGNPNDCNFMAVGGERTLLLMSKSERGFS 204
            .||..:|..:.:|...:    ||: |.||.. ...::.:|.|...:...|.....|....|....
Frog   128 FPEWQIIFWMWEKQKVM----ATVKPDSHSNPIYQVSFSPQDNTQICTTGHGVFKLFRYLEGNMK 188

  Fly   205 ISNNLKVK-YRVTSMAFLSLDLLMIGTSDDQLILVENG----EQKLAQKASDADTVDLMIDQEVF 264
            .:|..||: .......:||.|.::.||.:.:|.|.|:|    |..:..|:...
Frog   189 QTNFQKVEPQNFLCHTWLSEDRVICGTDNGKLSLWESGDLRWEINIGSKSGQT------------ 241

  Fly   265 DRDKE---LQEQRFLPTQAVSLPDRRVLCMTAFPKGFAYIIF-NRAFVFERV-SKFKFERKTILT 324
            |.:|.   .||.:....:..:....|:..:.|:.|||..... .:..:||:| .|..::|...:.
Frog   242 DHEKHSAYSQELQVTSAEHAAPAPVRINAILAYSKGFLCSAGPGKVCMFEKVEDKDFYKRSRDIR 306

  Fly   325 VPTNLYA-----EHMYQILNLAIDHKQETVIVTTSHCQIYVGILIVPETLKTKQLKFEPLGVLIH 384
            :|.:.|:     ....:|:.:.:...:|.|:::|:..|:|...|...|..|.:...||.|....|
Frog   307 IPQDEYSTDPTQSEQQEIVCMCLSPSEEMVLISTNKGQLYSIALSSAEISKGEDAYFEYLTESWH 371

  Fly   385 TGEIIAMSVCAWKPIIMTASRDQTIRIWNYETALVELVRKFQVDVNIVELSLTGQMAAIGFSDQL 449
            :..|..:|:|..||:|.|.|.|:::||||:|...:||.:::|.:...|.|..:|....:||||:|
Frog   372 SSSITGLSICVRKPLIATCSLDRSVRIWNFENNTLELYKEYQEEAYSVSLHPSGLYVLVGFSDKL 436

  Fly   450 RITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMAAAYDNNIAITSVYKLDVLINLKGHNGIVLSV 514
            |...:.:||:..||.:....|....:|:.||:.||...|.|.|......:.:.|||||||.|.||
Frog   437 RFMNLLIDDIRSVKEFTVRGCKECAFSHGGHLFAAVNGNVIHIYCTATFENITNLKGHNGKVRSV 501

  Fly   515 AWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGTEYVTISCSTNDPLTIYAGTSIGTIREFQ 579
            |||..|..|:|.|.:||:|.|:|..|.|..|.|.|...|.:::.| :|..||:|..|..|::|..
Frog   502 AWSSDDSKLVSCGLDGAVYEWNILLGKRESECVLKSCSYSSVAMS-SDSKTIFAVGSDQTLKEIS 565

  Fly   580 DSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLPF-LEAGGGTFTNFRFFDGPV 643
            ||.:|||  ||| ...:.:.|.::.|..::|.....|.:.:|:.|. |:.   .|..::....||
Frog   566 DSQIMRE--IPS-FDVTYTAVAVSHSGRMIFTGTSLGTIRSMKYPLPLQK---EFNEYQAHAKPV 624

  Fly   644 NKLRFSYDGTLLFAISNKGTLAIWAMDNIEGKVPYMDQDLMRSQEVLIPRSQLNDKIEQIANLEL 708
            .:|..::|...|.::|..|.|.:|.:.:.||:....|:::..::||||.:|.|.:|.:.:..|:.
Frog   625 TRLVVTFDDQYLLSVSEDGCLILWKISDKEGRGLKRDKEVGYAEEVLITKSDLEEKNQVMLELKT 689

  Fly   709 RLKQQAEEFQYQLSQNEIFDGQQLQEVHRSYCSALEELKELNNEI-------EARHTEEMNHITF 766
            |:::...|.:|||...::...::|:|:...:...:|.||..|..:       :.:|.|:
Frog   690 RVEELKMENEYQLRLKDMNYNEKLKELTEKFIQEMEVLKTTNQILKTDSERQDIKHQED------ 748

  Fly   767 QINSIREEHRIQLDTLATQYSERMLIEYQKFTNLRENMLELRESYEDKLKNSTGTLQDTVEALEN 831
             :..:.|:...::..|.|..|:::|:||:|:..|:.....::|.||.:|.....:....:|.:..
Frog   749 -VAELLEKQSREIQDLETSNSQKLLLEYEKYQELQLKSQRMQEEYEKQLHELEESKIQALEEITE 812

  Fly   832 NYKQQLNERKELIRDLMKEMQDKKAEFIEYCREVELENDRNMVSTQTEYENKLTTERNETQMWRG 896
            :|:.:|.|:..:::....|.:....||.|..:::|.:.||.:...:..||.:|..|:..:...:|
Frog   813 HYEAKLQEKMSVLQLTQDESRQHLREFEETKKQIEEDGDREIQDMKIRYERRLREEKESSLRLKG 877

  Fly   897 KAGVLQKKFESQSREIDNLLEEVEILKEEHHKSQRNIQKQMRNIEDLQKDIADRDYAINGKEKRI 961
            ::|:::|||.|..:||:....::|.:|.|..|.|..|:...::|..|:::|.:||..|..|||||
Frog   878 ESGIMRKKFSSLQKEIEERAADIEKMKAEQQKLQGVIKSLEKDILGLKREIQERDETIQDKEKRI 942

  Fly   962 QDLLHKNQELDKYKQVLGHKIAELKAQIEPREFQINDKRKHIIEMEAELEGLNQNNVQLELQLKE 1026
            .||..|||||:|:|.||.:||.|||.||||||.:|.:.::.|.|||:|||..::.|.||:|.:.|
Frog   943 YDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKEMKEQIQEMESELERFHKQNSQLDLNIAE 1007

  Fly  1027 MRDKYLSNVAELRTERHRAKASRECLHSICSDIYYVAGEINSAEALKKAVKELFRKHASDDELKR 1091
            ::.|..:...|:..||.:.:.....:....:|::...|.|...:.||..::||:.|:..|.::..
Frog  1008 LKQKLKATDREMHKERQKVRDIEAVVKRFKTDLHNCVGFIQEPKMLKDNIRELYSKYVQDSDVAE 1072

  Fly  1092 FVTLDAEVRDEFMRQRRQIENVLDR-YKSVAEDKSVQKKYD-KLFKENVILIEEIEKLNETNKML 1154
            .|.:||:::.|:.|||..:|..|.. .|.:|:|..:.:..: ::.:|||.||:||..|....|:.
Frog  1073 IVGVDADIQREYARQREHLERSLSTLQKKLAKDTEIHRTDNVRVMQENVTLIKEINDLRRELKLS 1137

  Fly  1155 RSKVKE 1160
            |:||.:
Frog  1138 RTKVHD 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4329	NP_611687.1	WD40 repeat	124..167	CDD:293791	9/43 (21%)
		WD40 repeat	173..211	CDD:293791	6/37 (16%)
		WD40 repeat	215..248	CDD:293791	10/36 (28%)
		WD40 repeat	288..324	CDD:293791	9/37 (24%)
		WD40	<328..667	CDD:225201	113/344 (33%)
		WD40 repeat	338..383	CDD:293791	11/44 (25%)
		WD40	384..668	CDD:295369	100/284 (35%)
		WD40 repeat	388..426	CDD:293791	16/37 (43%)
		WD40 repeat	430..466	CDD:293791	13/35 (37%)
		WD40 repeat	470..505	CDD:293791	10/34 (29%)
		WD40 repeat	511..548	CDD:293791	18/36 (50%)
		WD40 repeat	554..576	CDD:293791	7/21 (33%)
		WD40 repeat	597..634	CDD:293791	7/37 (19%)
		WD40 repeat	643..669	CDD:293791	8/25 (32%)
		Apolipoprotein	701..864	CDD:279749	35/169 (21%)
		MSP1_C	784..>1011	CDD:284802	79/226 (35%)
		Ax_dynein_light	<958..1026	CDD:287215	38/67 (57%)
cfap57	XP_002931652.2	WD40	2..450	CDD:225201	120/467 (26%)
		WD40 repeat	61..104	CDD:293791	14/43 (33%)
		WD40 repeat	111..149	CDD:293791	9/41 (22%)
		WD40 repeat	156..193	CDD:293791	6/36 (17%)
		WD40 repeat	201..233	CDD:293791	10/31 (32%)
		WD40 repeat	268..313	CDD:293791	10/44 (23%)
		WD40 repeat	324..364	CDD:293791	9/39 (23%)
		WD40	371..649	CDD:392136	100/284 (35%)
		WD40 repeat	375..414	CDD:293791	16/38 (42%)
		WD40 repeat	417..493	CDD:293791	24/75 (32%)
		WD40 repeat	498..535	CDD:293791	18/36 (50%)
		WD40 repeat	541..577	CDD:293791	16/39 (41%)
		WD40 repeat	583..616	CDD:293791	8/35 (23%)
		WD40 repeat	624..650	CDD:293791	8/25 (32%)
		PRK12704	664..>853	CDD:237177	44/195 (23%)
		Smc	<765..1135	CDD:224117	119/369 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1935
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H51350
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1406
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368770at33208
OrthoFinder	1	1.000	-	-		FOG0007926
OrthoInspector	1	1.000	-	-		oto104917
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060