DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tous and cfap57

DIOPT Version :10

Sequence 1:NP_611687.1 Gene:tous / 37582 FlyBaseID:FBgn0034745 Length:1171 Species:Drosophila melanogaster
Sequence 2:XP_002931652.2 Gene:cfap57 / 100496984 XenbaseID:XB-GENE-6032538 Length:1226 Species:Xenopus tropicalis


Alignment Length:1176 Identity:341/1176 - (28%)
Similarity:604/1176 - (51%) Gaps:66/1176 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 STVTIRPRLIYGLRSDVIGNIHFNLTKEVIYPVEGVLAFHDYVQNKQRFLRLPEDTR-PEVISIS 80
            |.:..:...|:||||.|..||.:...:.:|:|.......::..|..|:|:...|.:: .:.::||
 Frog     2 SVIVAQSHYIFGLRSPVTNNIFYFDEQTIIFPSGNNCVKYNVDQKWQKFIPGSEKSQGMQALAIS 66

  Fly    81 SHRKLLAVVERHSKNGRYISIYELATL--KKRRHLELP--SNHRNAEIQQMIFTNDSRSVALITR 141
            .:|:.||:.|:..:... ::||:||::  |||:.|..|  :.|   |...:.|:.||:.:...:.
 Frog    67 PNRRYLAMSEKGLEKAT-VTIYDLASVPFKKRKVLSAPDLTAH---EFVSIAFSPDSKYLVAQSG 127

  Fly   142 PPEETLIMLVLDKTSTVIEGRATI-PGSHGG-AECIAGNPNDCNFMAVGGERTLLLMSKSERGFS 204
            .||..:|..:.:|...:    ||: |.||.. ...::.:|.|...:...|.....|....|....
 Frog   128 FPEWQIIFWMWEKQKVM----ATVKPDSHSNPIYQVSFSPQDNTQICTTGHGVFKLFRYLEGNMK 188

  Fly   205 ISNNLKVK-YRVTSMAFLSLDLLMIGTSDDQLILVENG----EQKLAQKASDADTVDLMIDQEVF 264
            .:|..||: .......:||.|.::.||.:.:|.|.|:|    |..:..|:...            
 Frog   189 QTNFQKVEPQNFLCHTWLSEDRVICGTDNGKLSLWESGDLRWEINIGSKSGQT------------ 241

  Fly   265 DRDKE---LQEQRFLPTQAVSLPDRRVLCMTAFPKGFAYIIF-NRAFVFERV-SKFKFERKTILT 324
            |.:|.   .||.:....:..:....|:..:.|:.|||..... .:..:||:| .|..::|...:.
 Frog   242 DHEKHSAYSQELQVTSAEHAAPAPVRINAILAYSKGFLCSAGPGKVCMFEKVEDKDFYKRSRDIR 306

  Fly   325 VPTNLYA-----EHMYQILNLAIDHKQETVIVTTSHCQIYVGILIVPETLKTKQLKFEPLGVLIH 384
            :|.:.|:     ....:|:.:.:...:|.|:::|:..|:|...|...|..|.:...||.|....|
 Frog   307 IPQDEYSTDPTQSEQQEIVCMCLSPSEEMVLISTNKGQLYSIALSSAEISKGEDAYFEYLTESWH 371

  Fly   385 TGEIIAMSVCAWKPIIMTASRDQTIRIWNYETALVELVRKFQVDVNIVELSLTGQMAAIGFSDQL 449
            :..|..:|:|..||:|.|.|.|:::||||:|...:||.:::|.:...|.|..:|....:||||:|
 Frog   372 SSSITGLSICVRKPLIATCSLDRSVRIWNFENNTLELYKEYQEEAYSVSLHPSGLYVLVGFSDKL 436

  Fly   450 RITQIFMDDLNIVKTYNFPHCNAVRYSNFGHMMAAAYDNNIAITSVYKLDVLINLKGHNGIVLSV 514
            |...:.:||:..||.:....|....:|:.||:.||...|.|.|......:.:.|||||||.|.||
 Frog   437 RFMNLLIDDIRSVKEFTVRGCKECAFSHGGHLFAAVNGNVIHIYCTATFENITNLKGHNGKVRSV 501

  Fly   515 AWSRTDKFLISGGAEGAIYLWDIETGARLQEIVQKGTEYVTISCSTNDPLTIYAGTSIGTIREFQ 579
            |||..|..|:|.|.:||:|.|:|..|.|..|.|.|...|.:::.| :|..||:|..|..|::|..
 Frog   502 AWSSDDSKLVSCGLDGAVYEWNILLGKRESECVLKSCSYSSVAMS-SDSKTIFAVGSDQTLKEIS 565

  Fly   580 DSTLMREITIPSRTKGSVSDVCLARSDLIMFVADHEGNLFNMQLPF-LEAGGGTFTNFRFFDGPV 643
            ||.:|||  ||| ...:.:.|.::.|..::|.....|.:.:|:.|. |:.   .|..::....||
 Frog   566 DSQIMRE--IPS-FDVTYTAVAVSHSGRMIFTGTSLGTIRSMKYPLPLQK---EFNEYQAHAKPV 624

  Fly   644 NKLRFSYDGTLLFAISNKGTLAIWAMDNIEGKVPYMDQDLMRSQEVLIPRSQLNDKIEQIANLEL 708
            .:|..::|...|.::|..|.|.:|.:.:.||:....|:::..::||||.:|.|.:|.:.:..|:.
 Frog   625 TRLVVTFDDQYLLSVSEDGCLILWKISDKEGRGLKRDKEVGYAEEVLITKSDLEEKNQVMLELKT 689

  Fly   709 RLKQQAEEFQYQLSQNEIFDGQQLQEVHRSYCSALEELKELNNEI-------EARHTEEMNHITF 766
            |:::...|.:|||...::...::|:|:...:...:|.||..|..:       :.:|.|:      
 Frog   690 RVEELKMENEYQLRLKDMNYNEKLKELTEKFIQEMEVLKTTNQILKTDSERQDIKHQED------ 748

  Fly   767 QINSIREEHRIQLDTLATQYSERMLIEYQKFTNLRENMLELRESYEDKLKNSTGTLQDTVEALEN 831
             :..:.|:...::..|.|..|:::|:||:|:..|:.....::|.||.:|.....:....:|.:..
 Frog   749 -VAELLEKQSREIQDLETSNSQKLLLEYEKYQELQLKSQRMQEEYEKQLHELEESKIQALEEITE 812

  Fly   832 NYKQQLNERKELIRDLMKEMQDKKAEFIEYCREVELENDRNMVSTQTEYENKLTTERNETQMWRG 896
            :|:.:|.|:..:::....|.:....||.|..:::|.:.||.:...:..||.:|..|:..:...:|
 Frog   813 HYEAKLQEKMSVLQLTQDESRQHLREFEETKKQIEEDGDREIQDMKIRYERRLREEKESSLRLKG 877

  Fly   897 KAGVLQKKFESQSREIDNLLEEVEILKEEHHKSQRNIQKQMRNIEDLQKDIADRDYAINGKEKRI 961
            ::|:::|||.|..:||:....::|.:|.|..|.|..|:...::|..|:::|.:||..|..|||||
 Frog   878 ESGIMRKKFSSLQKEIEERAADIEKMKAEQQKLQGVIKSLEKDILGLKREIQERDETIQDKEKRI 942

  Fly   962 QDLLHKNQELDKYKQVLGHKIAELKAQIEPREFQINDKRKHIIEMEAELEGLNQNNVQLELQLKE 1026
            .||..|||||:|:|.||.:||.|||.||||||.:|.:.::.|.|||:|||..::.|.||:|.:.|
 Frog   943 YDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKEMKEQIQEMESELERFHKQNSQLDLNIAE 1007

  Fly  1027 MRDKYLSNVAELRTERHRAKASRECLHSICSDIYYVAGEINSAEALKKAVKELFRKHASDDELKR 1091
            ::.|..:...|:..||.:.:.....:....:|::...|.|...:.||..::||:.|:..|.::..
 Frog  1008 LKQKLKATDREMHKERQKVRDIEAVVKRFKTDLHNCVGFIQEPKMLKDNIRELYSKYVQDSDVAE 1072

  Fly  1092 FVTLDAEVRDEFMRQRRQIENVLDR-YKSVAEDKSVQKKYD-KLFKENVILIEEIEKLNETNKML 1154
            .|.:||:::.|:.|||..:|..|.. .|.:|:|..:.:..: ::.:|||.||:||..|....|:.
 Frog  1073 IVGVDADIQREYARQREHLERSLSTLQKKLAKDTEIHRTDNVRVMQENVTLIKEINDLRRELKLS 1137

  Fly  1155 RSKVKE 1160
            |:||.:
 Frog  1138 RTKVHD 1143

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tousNP_611687.1 WD40 repeat 124..167 CDD:293791 9/43 (21%)
WD40 repeat 173..211 CDD:293791 6/37 (16%)
WD40 repeat 215..248 CDD:293791 10/36 (28%)
WD40 repeat 288..324 CDD:293791 9/37 (24%)
WD40 repeat 338..383 CDD:293791 11/44 (25%)
WD40 384..668 CDD:475233 100/284 (35%)
WD40 repeat 388..426 CDD:293791 16/37 (43%)
WD40 repeat 430..466 CDD:293791 13/35 (37%)
WD40 repeat 470..505 CDD:293791 10/34 (29%)
WD40 repeat 511..548 CDD:293791 18/36 (50%)
WD40 repeat 554..576 CDD:293791 7/21 (33%)
WD40 repeat 597..634 CDD:293791 7/37 (19%)
WD40 repeat 643..669 CDD:293791 8/25 (32%)
Apolipoprotein 701..860 CDD:460211 34/165 (21%)
SMC_N <800..1169 CDD:481474 117/363 (32%)
cfap57XP_002931652.2 WD40 <26..167 CDD:441893 37/148 (25%)
WD40 repeat 61..104 CDD:293791 14/43 (33%)
WD40 105..435 CDD:475233 85/348 (24%)
WD40 repeat 111..149 CDD:293791 9/41 (22%)
WD40 repeat 156..193 CDD:293791 6/36 (17%)
WD40 repeat 201..233 CDD:293791 10/31 (32%)
WD40 repeat 268..313 CDD:293791 10/44 (23%)
WD40 repeat 324..364 CDD:293791 9/39 (23%)
WD40 <371..652 CDD:441893 101/287 (35%)
WD40 repeat 375..414 CDD:293791 16/38 (42%)
WD40 repeat 417..493 CDD:293791 24/75 (32%)
WD40 repeat 498..535 CDD:293791 18/36 (50%)
WD40 repeat 541..577 CDD:293791 16/39 (41%)
WD40 repeat 583..616 CDD:293791 8/35 (23%)
WD40 repeat 624..650 CDD:293791 8/25 (32%)
PRK12704 664..>853 CDD:237177 44/195 (23%)
SMC_prok_B <790..1156 CDD:274008 116/354 (33%)

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