DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGRN and Agrn

DIOPT Version :9

Sequence 1:	NP_001292204.1	Gene:	AGRN / 375790	HGNCID:	329	Length:	2068	Species:	Homo sapiens
Sequence 2:	XP_006538554.1	Gene:	Agrn / 11603	MGIID:	87961	Length:	2057	Species:	Mus musculus

Alignment Length:	2063	Identity:	1688/2063 - (81%)
Similarity:	1808/2063 - (87%)	Gaps:	13/2063 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     5 SHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVR 69
            |.|.||.|||.||..||..:|||.|||||||||||||||||||||||||||||||||||||||||
Mouse     7 SFPAPLLPLLLLLAAAAPAVPGASGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVR 71

Human    70 VWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELML 134
            |||||||||:||:||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse    72 VWRYLKGKDVVAQESLLDGGNKVVIGGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELML 136

Human   135 NSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKK 199
            ||||||||||||||||||||||||.|||..|..|||.||||||||||||||:.|.||||||||||
Mouse   137 NSSLMRITLRNLEEVEFCVEDKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKK 201

Human   200 SPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSAD 264
            :.||::|||||||||||||||||||||||:||||||||.:|||||||||:||||||||||..|||
Mouse   202 NVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSAD 266

Human   265 GLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSR 329
            |.|||||||.||.|||:||||||||.|||.||||||.|||.||::|||||||||||||::.|.:.
Mouse   267 GQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNH 331

Human   330 SCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQ 394
            .||||||||.||||||||:|||:..|:||||||||||||||.|.|||||||||||||||||.|||
Mouse   332 ICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQ 396

Human   395 CPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQG 459
            |||.|:||:|||||||||.||||||||||||||||||||.|||:||||||||||||:.||.||||
Mouse   397 CPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQG 461

Human   460 PCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGR 524
            ||||.||||.|.||||||||.||||:|.|||.:.||..||||||||||||||.||||:.||||||
Mouse   462 PCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGR 526

Human   525 EIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQI 589
            ||:|||:||||||||||||:|||.||||||||||||..||||||||||||.|||.||||||||||
Mouse   527 EIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQI 591

Human   590 SLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQT 654
            ||:|||||.|:|||:.||.|||||||||||||||||||||||||||||||.||||||||||.||.
Mouse   592 SLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQV 656

Human   655 QIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCG 719
            |||||||||||.|||||||||||||..||||||||.||:|||||||||||||||||||..|||||
Mouse   657 QIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCG 721

Human   720 SDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGV 784
            ||||||||||.|||||||:::.|||||||||||||.|||.|:|..|||||||||||||:|||:||
Mouse   722 SDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGV 786

Human   785 GLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSC 849
            |||||||.|.|||||||.|||||.||||||||||||||||||||||||||||||||.||||||||
Mouse   787 GLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSC 851

Human   850 DPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVE 914
            ||:||||||||||||||||:||||||||||||||:|||..|||||.:.|.||.||.|||||.|||
Mouse   852 DPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVE 916

Human   915 ESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHP 979
            |:|.|.||||.|||||||:||||||||||||||||||||||||.|.|||||||||:|:|||...|
Mouse   917 EAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSP 981

Human   980 TSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPT 1044
            ||||  :|||..:||:.|.:|..:|||:||:|||...||.|:| |:|....||:|.        .
Mouse   982 TSAS--MTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTS-PQTVVGTPRSTA--------A 1035

Human  1045 APSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSA 1109
            .||...||..:.|.|||||:||.|||||||:||||||||||||..||.|.|.|||:||||||||.
Mouse  1036 TPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSP 1100

Human  1110 LGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLD 1174
            |||||||||||||:|||||||||.|||||||||||||||||||||||||||||||||||||||||
Mouse  1101 LGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLD 1165

Human  1175 DLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRR 1239
            ||||||||||||.|:|||:|||||.|||||||||||||||:||||.:|||:||||||..:|.|||
Mouse  1166 DLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRR 1230

Human  1240 PLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAA 1304
            ||:|||||:||||||.|.|||.:|..||.|||||||.|||.:|:||||. :||:||:||.:|||.
Mouse  1231 PLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRV-YPSYTSRPVGRTTAP 1294

Human  1305 PTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKV 1369
            .||||||||..| :...|.|.||:|||.||||||.|||||||...|.||:|||.|||.|.|||||
Mouse  1295 LTTRRPPTTTAS-IDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKV 1358

Human  1370 LGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRF 1434
            ....||||:|.||||||||||||||||||||||||.:||||||||||||||||||||||.||.||
Mouse  1359 QLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRF 1423

Human  1435 DTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVP 1499
            |||||||||||.||||||:|||||||||||:||||||||.||:||||||||||||||.|:|||:|
Mouse  1424 DTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLP 1488

Human  1500 EDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPC 1564
            |:|.|..|:||.||.||:||||:||:|||:|||.....|..:.|||||||||||.||||||||.|
Mouse  1489 EEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALC 1553

Human  1565 QNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASG 1629
            |.||||.|.|||||||.||||||||:|||||||||:|||.||..|||:|.|||||.|:||:|...
Mouse  1554 QALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLE 1618

Human  1630 QDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLA 1694
            ..||.||||||||||:|||:|||||.||||||||||:||||||||||||||||||||||||||||
Mouse  1619 NAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLA 1683

Human  1695 LRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHT 1759
            |.:|.||||||||||||:|||:||:.||.|.||.||||||||||:||||||||||||||||||||
Mouse  1684 LHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHT 1748

Human  1760 VLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTR 1824
            :||||||||||||||||||||.|||:||||||||||||.|.||||.|||||.|||..|||||||:
Mouse  1749 MLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQ 1813

Human  1825 ASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESE 1889
            |..:|||||.||:||||.|.|||||||||.|||||:||||.||::||||||||::||||||||||
Mouse  1814 AVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESE 1878

Human  1890 LANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLS 1954
            |.||||.||||||.||.|||||||||||||||||||||||||.||..|||||:||||||||||||
Mouse  1879 LTNEIPAPETLDSRALFSEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLS 1943

Human  1955 YNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGL 2019
            |:||||||||||||.|||||||||.||||.|||||||||||||||||||||||||||||||||||
Mouse  1944 YDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGL 2008

Human  2020 PELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPT 2067
            .:||||.||||||||||||||||||||...||||||||||||||||||
Mouse  2009 QKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPT 2056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGRN	NP_001292204.1	NtA	44..146	CDD:308653	98/101 (97%)
		KAZAL	196..242	CDD:197624	38/45 (84%)
		KAZAL	272..317	CDD:197624	35/44 (80%)
		KAZAL_FS	349..389	CDD:320757	33/39 (85%)
		KAZAL_FS	421..461	CDD:238052	34/39 (87%)
		KAZAL	489..534	CDD:197624	34/44 (77%)
		KAZAL	554..599	CDD:197624	39/44 (89%)
		KAZAL	619..664	CDD:197624	41/44 (93%)
		KAZAL	704..750	CDD:197624	38/45 (84%)
		Laminin_EGF	793..835	CDD:278482	38/41 (93%)
		Laminin_EGF	847..>883	CDD:278482	33/35 (94%)
		KAZAL	922..969	CDD:197624	42/46 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	995..1096		53/100 (53%)
		SEA	1130..1254	CDD:214554	108/123 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1334		33/56 (59%)
		EGF	1333..1363	CDD:306513	22/29 (76%)
		Laminin_G_1	1400..1531	CDD:278483	107/130 (82%)
		EGF_CA	1555..1585	CDD:238011	24/29 (83%)
		Laminin_G_1	1668..1803	CDD:278483	118/134 (88%)
		EGF_CA	1825..1857	CDD:238011	23/31 (74%)
		Laminin_G_1	1921..2051	CDD:278483	115/129 (89%)
Agrn	XP_006538554.1	NtA	46..148	CDD:367356	98/101 (97%)
		KAZAL	198..244	CDD:197624	38/45 (84%)
		KAZAL	274..319	CDD:197624	35/44 (80%)
		Kazal_1	351..391	CDD:333798	33/39 (85%)
		KAZAL_FS	423..463	CDD:238052	34/39 (87%)
		KAZAL	491..536	CDD:197624	34/44 (77%)
		KAZAL	556..601	CDD:197624	39/44 (89%)
		KAZAL	621..666	CDD:197624	41/44 (93%)
		KAZAL	706..752	CDD:197624	38/45 (84%)
		EGF_Lam	795..835	CDD:238012	36/39 (92%)
		Laminin_EGF	849..>885	CDD:365839	33/35 (94%)
		KAZAL	924..971	CDD:197624	42/46 (91%)
		SEA	1121..1245	CDD:214554	108/123 (88%)
		EGF	1322..1352	CDD:333761	22/29 (76%)
		Laminin_G_1	1389..1520	CDD:333802	107/130 (82%)
		Laminin_G_1	1657..1792	CDD:333802	118/134 (88%)
		EGF_CA	1814..1846	CDD:238011	23/31 (74%)
		Laminin_G_1	1910..2040	CDD:333802	115/129 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83971212
Domainoid	1	1.000	242	1.000	Domainoid score	I20545
eggNOG	1	0.900	-	-		E1_KOG3509
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27907
Inparanoid	1	1.050	3281	1.000	Inparanoid score	I491
Isobase	1	0.950	-	0	Normalized mean entropy	S7617
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43447
OrthoDB	1	1.010	-	-		D17288at33208
OrthoFinder	1	1.000	-	-		FOG0009495
OrthoInspector	1	1.000	-	-		oto116058
orthoMCL	1	0.900	-	-		OOG6_105350
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3299
SonicParanoid	1	1.000	-	-		X7235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	19	19.250